Clinical and virological findings in mixed cryoglobulinaemia

C. Mazzaro, P. Tulissi, M. Moretti, L. Mazzoran, E. Pussini, M. Crovatto, G. F. Santini, G. Pozzato

Research output: Contribution to journalArticlepeer-review


Objectives. As a close relationship has been established between mixed cryoglobulinaemia and hepatitis C virus (HCV) infection, the clinical, histological and virological findings of patients affected by mixed cryoglobulinaemia were determined. Design. Hepatitis C virus infection was investigated by the presence of anti-HCV antibodies and PCR application of the 52 untranslated region (52 UTR), and the genotype of HCV was also determined according to Okamoto. A bone marrow biopsy was performed in all patients and liver and kidney biopsies when indicated. Subjects. Eighty-two subjects affected by mixed cryoglobulinaemia were enrolled in this study. Results. The prevalence of anti-HCV antibodies was high (83%); PCR amplification of the 5'UTR region was performed in 52 subjects and in 44 of them (85%) the results were positive. In the same subjects, the Core region amplification was positive in 46 cases (88%). A high prevalence of genotype II was found (54%). Chronic liver disease was present in 55 patients (67%). Bone marrow biopsies showed the presence of low-grade non-Hodgkin's lymphomas in 11 cases (13%). Membrano-proliferative glomerulonephritis was found in seven subjects (8%). Conclusions. Mixed cryoglobulinaemia is associated with HCV infection in the nearly all cases. Several HCV genotypes are involved m the pathogenesis of this disease. Mixed cryoglobulinaemia is associated with a high prevalence of chronic liver disease, low-grade non-Hodgkin's lymphomas and membrano-proliferative glomerulonephritis.

Original languageEnglish
Pages (from-to)153-160
Number of pages8
JournalJournal of Internal Medicine
Issue number2
Publication statusPublished - 1995


  • Hepatitis C virus
  • Mixed cryoglobulinaemia
  • Non-Hodgkin's lymphomas

ASJC Scopus subject areas

  • Internal Medicine


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