Clinical and virological survey of patients with hepatitis B surface antigen in an Italian region: Clinical considerations and disease burden

Francesco Torre, Monica Basso, Edoardo G. Giannini, Marcello Feasi, Silvia Boni, Alessandro Grasso, Pasqualina De Leo, Ferdinando Dodi, Maria Grazia Marazzi, Emilio Azzola, Valentina Bartolacci, Gianfranco Percario, Andrea Beltrame, Paolo Borro, Antonino Picciotto

Research output: Contribution to journalArticle

Abstract

The aim of this study was to determine the prevalence of hepatitis B virus (HBV) infection in an Italian region, Liguria (1,572,000 inhabitants), by means of a network of 12 referral centers for liver diseases. All patients with HBV surface antigen followed throughout 2006 were included. Personal data, infectious status with risk factors, other non-infectious risk factors for liver disease, clinical status, and treatment were the questionnaire. Four hundred forty-five patients (71% male) were evaluated. Their median age was 48 years (range 5-84), and 83.4% were of Italian origin. Community-acquired infection was the principal mode of HBV transmission (82.5%), followed by previous intravenous drug use (9.4%), perinatal transmission (6.3%), and transfusion-associated transmission (1.8%). Hepatitis B e-antigen was present in 20.4% of the patients, while co-infections with hepatitis D virus and/or hepatitis C virus and/or human immunodeficiency virus (HIV) were observed in 18.7% of the patients. Chronic active hepatitis was present in 62.5% of the patients, cirrhosis in 13.5%, hepatocellular carcinoma in 2.2%, and 21.8% of the patients were inactive carriers of HBV. In all, 42.5% of the patients were treated with interferon or lamivudine and/or adefovir-dipivoxil. Forty-nine patients were co-infected with HIV (86% on highly active antiviral therapy). Nevertheless, this study identified only 2.2% of the expected patients with HBV. Hence, it has to be reasoned that few potential infectious or treatable patients are referred to liver disease centers. HBV infection is still an underestimated health problem, and few potential infectious or treatable patients are referred to tertiary centers.

Original languageEnglish
Pages (from-to)1882-1886
Number of pages5
JournalJournal of Medical Virology
Volume81
Issue number11
DOIs
Publication statusPublished - Nov 2009

Fingerprint

Hepatitis B Surface Antigens
Hepatitis B virus
Liver Diseases
Virus Diseases
Surveys and Questionnaires
HIV
Hepatitis Delta Virus
Community-Acquired Infections
Lamivudine
Hepatitis B e Antigens
Chronic Hepatitis
Coinfection
Hepacivirus
Interferons
Antiviral Agents
Hepatocellular Carcinoma
Fibrosis
Referral and Consultation

Keywords

  • Co-infection
  • Disease burden
  • Epidemiology
  • Hepatitis B virus

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Clinical and virological survey of patients with hepatitis B surface antigen in an Italian region : Clinical considerations and disease burden. / Torre, Francesco; Basso, Monica; Giannini, Edoardo G.; Feasi, Marcello; Boni, Silvia; Grasso, Alessandro; De Leo, Pasqualina; Dodi, Ferdinando; Marazzi, Maria Grazia; Azzola, Emilio; Bartolacci, Valentina; Percario, Gianfranco; Beltrame, Andrea; Borro, Paolo; Picciotto, Antonino.

In: Journal of Medical Virology, Vol. 81, No. 11, 11.2009, p. 1882-1886.

Research output: Contribution to journalArticle

Torre, F, Basso, M, Giannini, EG, Feasi, M, Boni, S, Grasso, A, De Leo, P, Dodi, F, Marazzi, MG, Azzola, E, Bartolacci, V, Percario, G, Beltrame, A, Borro, P & Picciotto, A 2009, 'Clinical and virological survey of patients with hepatitis B surface antigen in an Italian region: Clinical considerations and disease burden', Journal of Medical Virology, vol. 81, no. 11, pp. 1882-1886. https://doi.org/10.1002/jmv.21523
Torre, Francesco ; Basso, Monica ; Giannini, Edoardo G. ; Feasi, Marcello ; Boni, Silvia ; Grasso, Alessandro ; De Leo, Pasqualina ; Dodi, Ferdinando ; Marazzi, Maria Grazia ; Azzola, Emilio ; Bartolacci, Valentina ; Percario, Gianfranco ; Beltrame, Andrea ; Borro, Paolo ; Picciotto, Antonino. / Clinical and virological survey of patients with hepatitis B surface antigen in an Italian region : Clinical considerations and disease burden. In: Journal of Medical Virology. 2009 ; Vol. 81, No. 11. pp. 1882-1886.
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abstract = "The aim of this study was to determine the prevalence of hepatitis B virus (HBV) infection in an Italian region, Liguria (1,572,000 inhabitants), by means of a network of 12 referral centers for liver diseases. All patients with HBV surface antigen followed throughout 2006 were included. Personal data, infectious status with risk factors, other non-infectious risk factors for liver disease, clinical status, and treatment were the questionnaire. Four hundred forty-five patients (71{\%} male) were evaluated. Their median age was 48 years (range 5-84), and 83.4{\%} were of Italian origin. Community-acquired infection was the principal mode of HBV transmission (82.5{\%}), followed by previous intravenous drug use (9.4{\%}), perinatal transmission (6.3{\%}), and transfusion-associated transmission (1.8{\%}). Hepatitis B e-antigen was present in 20.4{\%} of the patients, while co-infections with hepatitis D virus and/or hepatitis C virus and/or human immunodeficiency virus (HIV) were observed in 18.7{\%} of the patients. Chronic active hepatitis was present in 62.5{\%} of the patients, cirrhosis in 13.5{\%}, hepatocellular carcinoma in 2.2{\%}, and 21.8{\%} of the patients were inactive carriers of HBV. In all, 42.5{\%} of the patients were treated with interferon or lamivudine and/or adefovir-dipivoxil. Forty-nine patients were co-infected with HIV (86{\%} on highly active antiviral therapy). Nevertheless, this study identified only 2.2{\%} of the expected patients with HBV. Hence, it has to be reasoned that few potential infectious or treatable patients are referred to liver disease centers. HBV infection is still an underestimated health problem, and few potential infectious or treatable patients are referred to tertiary centers.",
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