Clinical application of ischemic preconditioning in the elderly

Pasquale Abete; Francesco Cacciatore; Gianluca Testa; David Della-Morte; Gianluigi Galizia; Nicola Ferrara; Franco Rengo

doi:10.2203/dose-response.09-023.Abete

Clinical application of ischemic preconditioning in the elderly

Pasquale Abete, Francesco Cacciatore, Gianluca Testa, David Della-Morte, Gianluigi Galizia, Nicola Ferrara, Franco Rengo

Research output: Contribution to journal › Article › peer-review

Abstract

A mild stress such as brief ischemic episodes may protect the heart from a successive and more prolonged myocardial ischemia (ischemic preconditioning). This phenomenon is considered a typical "hormetic mechanism" by which the heart is immunized from pathological insults such as myocardial ischemia. This mechanism is reduced with aging and it may be restored and/or preserved by drugs such as adenosine or nicorandil, a mitochondrial K_ATP channels, and lifestyle interventions such as physical activity and/or hypocaloric diet. Moreover, since the mechanisms involved in cardiac ischemic preconditioning have been established basic and clinical investigators are encouraged to test several drug in well-controlled animal and human studies in order to prevent and/or restore the age-related reduction of ischemic preconditioning.

Original language	English
Pages (from-to)	34-40
Number of pages	7
Journal	Dose-Response
Volume	8
Issue number	1
DOIs	https://doi.org/10.2203/dose-response.09-023.Abete
Publication status	Published - 2010

Keywords

Aging
Hormesis
Lifestyles
Preconditioning

ASJC Scopus subject areas

Toxicology
Health, Toxicology and Mutagenesis
Chemical Health and Safety
Public Health, Environmental and Occupational Health

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10.2203/dose-response.09-023.Abete

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AU - Abete, Pasquale

AU - Cacciatore, Francesco

AU - Testa, Gianluca

AU - Della-Morte, David

AU - Galizia, Gianluigi

AU - Ferrara, Nicola

AU - Rengo, Franco

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Clinical application of ischemic preconditioning in the elderly

Abstract

Keywords

ASJC Scopus subject areas

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