Abstract
A mild stress such as brief ischemic episodes may protect the heart from a successive and more prolonged myocardial ischemia (ischemic preconditioning). This phenomenon is considered a typical "hormetic mechanism" by which the heart is immunized from pathological insults such as myocardial ischemia. This mechanism is reduced with aging and it may be restored and/or preserved by drugs such as adenosine or nicorandil, a mitochondrial KATP channels, and lifestyle interventions such as physical activity and/or hypocaloric diet. Moreover, since the mechanisms involved in cardiac ischemic preconditioning have been established basic and clinical investigators are encouraged to test several drug in well-controlled animal and human studies in order to prevent and/or restore the age-related reduction of ischemic preconditioning.
Original language | English |
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Pages (from-to) | 34-40 |
Number of pages | 7 |
Journal | Dose-Response |
Volume | 8 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2010 |
Keywords
- Aging
- Hormesis
- Lifestyles
- Preconditioning
ASJC Scopus subject areas
- Toxicology
- Health, Toxicology and Mutagenesis
- Chemical Health and Safety
- Public Health, Environmental and Occupational Health