Clinical application of microRNA testing in neuroendocrine tumors of the gastrointestinal tract

Caterina Vicentini, Matteo Fassan, Edoardo D'Angelo, Vincenzo Corbo, Nicola Silvestris, Gerard J. Nuovo, Aldo Scarpa

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

It is well documented that dysregulation of microRNAs is a hallmark of human cancers. Thus, this family of small non-coding regulatory molecules represents an excellent source of sensitive biomarkers. Unique microRNAs expression profiles have been associated with different types and subsets of gastrointestinal tumors including gastroenteropancreatic neuroendocrine tumors (GEP-NETs). GEP-NETs are a heterogeneous group of epithelial neoplasms with neuroendocrine differentiation. At present, early detection and surgical resection of GEP-NETs represent the best chance for a cure. Thus, clinically useful biomarkers for GEP-NETs that strongly correlate with early detection are urgently needed. The purpose of this review is to summarize the role of miRNAs in GEP-NET carcinogenesis and their possible use as novel diagnostic, prognostic and predictive biomarkers.

Original languageEnglish
Pages (from-to)2458-2468
Number of pages11
JournalMolecules
Volume19
Issue number2
DOIs
Publication statusPublished - Feb 2014

Fingerprint

Neuroendocrine Tumors
MicroRNAs
Gastrointestinal Tract
Tumors
Testing
Biomarkers
Glandular and Epithelial Neoplasms
Neoplasms
Carcinogenesis
Gastro-enteropancreatic neuroendocrine tumor
Molecules

Keywords

  • Gastrointestinal tract
  • In situ hybridization
  • MiRNAs
  • Neuroendocrine tumors
  • Pancreas

ASJC Scopus subject areas

  • Organic Chemistry
  • Medicine(all)

Cite this

Vicentini, C., Fassan, M., D'Angelo, E., Corbo, V., Silvestris, N., Nuovo, G. J., & Scarpa, A. (2014). Clinical application of microRNA testing in neuroendocrine tumors of the gastrointestinal tract. Molecules, 19(2), 2458-2468. https://doi.org/10.3390/molecules19022458

Clinical application of microRNA testing in neuroendocrine tumors of the gastrointestinal tract. / Vicentini, Caterina; Fassan, Matteo; D'Angelo, Edoardo; Corbo, Vincenzo; Silvestris, Nicola; Nuovo, Gerard J.; Scarpa, Aldo.

In: Molecules, Vol. 19, No. 2, 02.2014, p. 2458-2468.

Research output: Contribution to journalArticle

Vicentini, C, Fassan, M, D'Angelo, E, Corbo, V, Silvestris, N, Nuovo, GJ & Scarpa, A 2014, 'Clinical application of microRNA testing in neuroendocrine tumors of the gastrointestinal tract', Molecules, vol. 19, no. 2, pp. 2458-2468. https://doi.org/10.3390/molecules19022458
Vicentini, Caterina ; Fassan, Matteo ; D'Angelo, Edoardo ; Corbo, Vincenzo ; Silvestris, Nicola ; Nuovo, Gerard J. ; Scarpa, Aldo. / Clinical application of microRNA testing in neuroendocrine tumors of the gastrointestinal tract. In: Molecules. 2014 ; Vol. 19, No. 2. pp. 2458-2468.
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