Clinical application of presepsin as diagnostic biomarker of infection: Overview and updates

Research output: Contribution to journalReview article


The appropriate identification of bacterial infection is the basis for effective treatment and control of infective disease. Among this context, an emerging biomarker of infection is presepsin (PSP), recently described as early marker of different infections. PSP secretion has been shown to be associated with monocyte phagocytosis and plasmatic levels of PSP increase in response to bacterial infection and decrease after antibiotic treatment, therefore it can be considered a marker of activation of immune cell response towards an invading pathogen. Different methods have been developed to measure PSP and this review will briefly describe the different clinical fields of application of PSP, ranging from intensive care to neonatal infection, to orthopedic and pulmonary infection as well as fungal infections and cardiovascular infections.

Original languageEnglish
Pages (from-to)11-17
Number of pages7
JournalClinical Chemistry and Laboratory Medicine
Issue number1
Publication statusPublished - Dec 2019



  • bacterial infection
  • presepsin
  • serum marker

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

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