Clinical applications of alpha1-receptor blockade: Terazosin in the management of hypertension

J. Rosenthal, J. J. Kyncl, P. Weidmann, O. Kuchel, K. Horky, [No Value] Ladu, C. Venkata, S. Ram, M. K. Brawer, P. Weidmann, P. Ferrari, A. Zanchetti

Research output: Contribution to journalArticle

Abstract

Four points summarize the apparent major effects of selective alpha1- inhibitors on lipid metabolism: stimulation of lipoprotein lipase; reduced VLDL synthesis and secretion; increase in the number of LDL receptors; and perhaps also a decrease in LDL cholesterol synthesis. Similar to the experimental data, the issues concern the type of patient, the clinical condition, normality, high cholesterol values or high triglyceride values, a combination of both, hypertension, and the degree of sympathetic activity.

Original languageEnglish
Pages (from-to)866-899
Number of pages34
JournalJournal of Clinical Pharmacology
Volume33
Issue number9
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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    Rosenthal, J., Kyncl, J. J., Weidmann, P., Kuchel, O., Horky, K., Ladu, N. V., Venkata, C., Ram, S., Brawer, M. K., Weidmann, P., Ferrari, P., & Zanchetti, A. (1993). Clinical applications of alpha1-receptor blockade: Terazosin in the management of hypertension. Journal of Clinical Pharmacology, 33(9), 866-899.