Clinical applications of alpha1-receptor blockade: Terazosin in the management of hypertension

J. Rosenthal, J. J. Kyncl, P. Weidmann, O. Kuchel, K. Horky, [No Value] Ladu, C. Venkata, S. Ram, M. K. Brawer, P. Weidmann, P. Ferrari, A. Zanchetti

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Four points summarize the apparent major effects of selective alpha1- inhibitors on lipid metabolism: stimulation of lipoprotein lipase; reduced VLDL synthesis and secretion; increase in the number of LDL receptors; and perhaps also a decrease in LDL cholesterol synthesis. Similar to the experimental data, the issues concern the type of patient, the clinical condition, normality, high cholesterol values or high triglyceride values, a combination of both, hypertension, and the degree of sympathetic activity.

Original languageEnglish
Pages (from-to)866-899
Number of pages34
JournalJournal of Clinical Pharmacology
Volume33
Issue number9
Publication statusPublished - 1993

Fingerprint

Terazosin
Lipoprotein Lipase
LDL Receptors
Lipid Metabolism
LDL Cholesterol
Triglycerides
Cholesterol
Hypertension

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Rosenthal, J., Kyncl, J. J., Weidmann, P., Kuchel, O., Horky, K., Ladu, N. V., ... Zanchetti, A. (1993). Clinical applications of alpha1-receptor blockade: Terazosin in the management of hypertension. Journal of Clinical Pharmacology, 33(9), 866-899.

Clinical applications of alpha1-receptor blockade : Terazosin in the management of hypertension. / Rosenthal, J.; Kyncl, J. J.; Weidmann, P.; Kuchel, O.; Horky, K.; Ladu, [No Value]; Venkata, C.; Ram, S.; Brawer, M. K.; Weidmann, P.; Ferrari, P.; Zanchetti, A.

In: Journal of Clinical Pharmacology, Vol. 33, No. 9, 1993, p. 866-899.

Research output: Contribution to journalArticle

Rosenthal, J, Kyncl, JJ, Weidmann, P, Kuchel, O, Horky, K, Ladu, NV, Venkata, C, Ram, S, Brawer, MK, Weidmann, P, Ferrari, P & Zanchetti, A 1993, 'Clinical applications of alpha1-receptor blockade: Terazosin in the management of hypertension', Journal of Clinical Pharmacology, vol. 33, no. 9, pp. 866-899.
Rosenthal J, Kyncl JJ, Weidmann P, Kuchel O, Horky K, Ladu NV et al. Clinical applications of alpha1-receptor blockade: Terazosin in the management of hypertension. Journal of Clinical Pharmacology. 1993;33(9):866-899.
Rosenthal, J. ; Kyncl, J. J. ; Weidmann, P. ; Kuchel, O. ; Horky, K. ; Ladu, [No Value] ; Venkata, C. ; Ram, S. ; Brawer, M. K. ; Weidmann, P. ; Ferrari, P. ; Zanchetti, A. / Clinical applications of alpha1-receptor blockade : Terazosin in the management of hypertension. In: Journal of Clinical Pharmacology. 1993 ; Vol. 33, No. 9. pp. 866-899.
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