Clinical applications of donor lymphocyte infusion from an HLA-haploidentical donor: consensus recommendations from the acute leukemia working party of the EBMT

Bhagirathbhai Dholaria, Bipin N Savani, Myriam Labopin, Leo Luznik, Annalisa Ruggeri, Stephan Mielke, Monzr M Al Malki, Piyanuch Kongtim, Ephraim Fuchs, Xiao-Jun Huang, Franco Locatelli, Franco Aversa, Luca Castagna, Andrea Bacigalupo, Massimo Martelli, Didier Blaise, Patrick Ben Soussan, Yolande Arnault, Rupert Handgretinger, Denis-Claude RoyPaul O'Donnell, Asad Bashey, Scott Solomon, Rizwan Romee, Philippe Lewalle, Jorge Gayoso, Michael Maschan, Hillard M Lazarus, Karen Ballen, Sebastian Giebel, Frederic Baron, Fabio Ciceri, Jordi Esteve, Norbert-Claude Gorin, Alexandros Spyridonidis, Christoph Schmid, Stefan O Ciurea, Arnon Nagler, Mohamad Mohty

Research output: Contribution to journalArticle

Abstract

Donor lymphocyte infusion has been used in the management of relapsed disease hematological malignancies after allogeneic hematopoietic cell transplantation. It can eradicate minimal residual disease or be used to rescue a hematological relapse, being able to induce durable remissions in a subset of patients. With the increased in the use of haploidentical hematopoietic cell transplantation, there is renewed interest in the use of donor lymphocytes to either treat or prevent disease relapse post-transplant. Published retrospective and small prospective studies have shown encouraging results with therapeutic donor lymphocyte infusion in different haploidentical transplantation platforms. In this consensus paper, finalized on behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation, we summarized the available evidence on the use of donor lymphocyte infusion from haploidentical donor and provide recommendations on its therapeutic, pre-emptive and prophylactic use in clinical practice.

Original languageEnglish
JournalHaematologica
DOIs
Publication statusE-pub ahead of print - Sep 19 2019

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Leukemia
Tissue Donors
Lymphocytes
Cell Transplantation
Transplantation
Recurrence
Residual Neoplasm
Hematologic Neoplasms
Disease Management
Bone Marrow
Prospective Studies
Transplants
Therapeutics

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Clinical applications of donor lymphocyte infusion from an HLA-haploidentical donor : consensus recommendations from the acute leukemia working party of the EBMT. / Dholaria, Bhagirathbhai; Savani, Bipin N; Labopin, Myriam; Luznik, Leo; Ruggeri, Annalisa; Mielke, Stephan; Al Malki, Monzr M; Kongtim, Piyanuch; Fuchs, Ephraim; Huang, Xiao-Jun; Locatelli, Franco; Aversa, Franco; Castagna, Luca; Bacigalupo, Andrea; Martelli, Massimo; Blaise, Didier; Ben Soussan, Patrick; Arnault, Yolande; Handgretinger, Rupert; Roy, Denis-Claude; O'Donnell, Paul; Bashey, Asad; Solomon, Scott; Romee, Rizwan; Lewalle, Philippe; Gayoso, Jorge; Maschan, Michael; Lazarus, Hillard M; Ballen, Karen; Giebel, Sebastian; Baron, Frederic; Ciceri, Fabio; Esteve, Jordi; Gorin, Norbert-Claude; Spyridonidis, Alexandros; Schmid, Christoph; Ciurea, Stefan O; Nagler, Arnon; Mohty, Mohamad.

In: Haematologica, 19.09.2019.

Research output: Contribution to journalArticle

Dholaria, B, Savani, BN, Labopin, M, Luznik, L, Ruggeri, A, Mielke, S, Al Malki, MM, Kongtim, P, Fuchs, E, Huang, X-J, Locatelli, F, Aversa, F, Castagna, L, Bacigalupo, A, Martelli, M, Blaise, D, Ben Soussan, P, Arnault, Y, Handgretinger, R, Roy, D-C, O'Donnell, P, Bashey, A, Solomon, S, Romee, R, Lewalle, P, Gayoso, J, Maschan, M, Lazarus, HM, Ballen, K, Giebel, S, Baron, F, Ciceri, F, Esteve, J, Gorin, N-C, Spyridonidis, A, Schmid, C, Ciurea, SO, Nagler, A & Mohty, M 2019, 'Clinical applications of donor lymphocyte infusion from an HLA-haploidentical donor: consensus recommendations from the acute leukemia working party of the EBMT', Haematologica. https://doi.org/10.3324/haematol.2019.219790
Dholaria, Bhagirathbhai ; Savani, Bipin N ; Labopin, Myriam ; Luznik, Leo ; Ruggeri, Annalisa ; Mielke, Stephan ; Al Malki, Monzr M ; Kongtim, Piyanuch ; Fuchs, Ephraim ; Huang, Xiao-Jun ; Locatelli, Franco ; Aversa, Franco ; Castagna, Luca ; Bacigalupo, Andrea ; Martelli, Massimo ; Blaise, Didier ; Ben Soussan, Patrick ; Arnault, Yolande ; Handgretinger, Rupert ; Roy, Denis-Claude ; O'Donnell, Paul ; Bashey, Asad ; Solomon, Scott ; Romee, Rizwan ; Lewalle, Philippe ; Gayoso, Jorge ; Maschan, Michael ; Lazarus, Hillard M ; Ballen, Karen ; Giebel, Sebastian ; Baron, Frederic ; Ciceri, Fabio ; Esteve, Jordi ; Gorin, Norbert-Claude ; Spyridonidis, Alexandros ; Schmid, Christoph ; Ciurea, Stefan O ; Nagler, Arnon ; Mohty, Mohamad. / Clinical applications of donor lymphocyte infusion from an HLA-haploidentical donor : consensus recommendations from the acute leukemia working party of the EBMT. In: Haematologica. 2019.
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abstract = "Donor lymphocyte infusion has been used in the management of relapsed disease hematological malignancies after allogeneic hematopoietic cell transplantation. It can eradicate minimal residual disease or be used to rescue a hematological relapse, being able to induce durable remissions in a subset of patients. With the increased in the use of haploidentical hematopoietic cell transplantation, there is renewed interest in the use of donor lymphocytes to either treat or prevent disease relapse post-transplant. Published retrospective and small prospective studies have shown encouraging results with therapeutic donor lymphocyte infusion in different haploidentical transplantation platforms. In this consensus paper, finalized on behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation, we summarized the available evidence on the use of donor lymphocyte infusion from haploidentical donor and provide recommendations on its therapeutic, pre-emptive and prophylactic use in clinical practice.",
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AU - Dholaria, Bhagirathbhai

AU - Savani, Bipin N

AU - Labopin, Myriam

AU - Luznik, Leo

AU - Ruggeri, Annalisa

AU - Mielke, Stephan

AU - Al Malki, Monzr M

AU - Kongtim, Piyanuch

AU - Fuchs, Ephraim

AU - Huang, Xiao-Jun

AU - Locatelli, Franco

AU - Aversa, Franco

AU - Castagna, Luca

AU - Bacigalupo, Andrea

AU - Martelli, Massimo

AU - Blaise, Didier

AU - Ben Soussan, Patrick

AU - Arnault, Yolande

AU - Handgretinger, Rupert

AU - Roy, Denis-Claude

AU - O'Donnell, Paul

AU - Bashey, Asad

AU - Solomon, Scott

AU - Romee, Rizwan

AU - Lewalle, Philippe

AU - Gayoso, Jorge

AU - Maschan, Michael

AU - Lazarus, Hillard M

AU - Ballen, Karen

AU - Giebel, Sebastian

AU - Baron, Frederic

AU - Ciceri, Fabio

AU - Esteve, Jordi

AU - Gorin, Norbert-Claude

AU - Spyridonidis, Alexandros

AU - Schmid, Christoph

AU - Ciurea, Stefan O

AU - Nagler, Arnon

AU - Mohty, Mohamad

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