CLINICAL APPLICATIONS OF SCANNING ELECTRON MICROSCOPY IN GASTROINTESTINAL DISEASES.

F. Bonvicini, G. Zoli, M. C. Maltarello, D. Bianchi, G. Pasquinelli, P. Versura, G. Gasbarrini, R. Laschi

Research output: Contribution to journalArticle

Abstract

We considered the role of scanning electron microscopy (SEM) in clinical investigation of different gastrointestinal diseases. The following clinical applications of SEM may be suggested on the basis of our original data and those reported in literature: 1) in peptic ulcer: assessment of the completeness of healing, by observing the mucosal surface architecture of the scars; identification of mucosal changes, namely entercytic surface membrane alterations, predictive of recurrence; 2) in coeliac disease: early assessment of the response to gluten-free diet and follow-up of the patients by staging the process of mucosal repair in cerebriform, intermediate and villous patterns; and 3) in ulcerative and Crohn's colitis: enhancement of the diagnostic sensitivity of perendoscopic biopsy, by detecting differences in surface structure of mucosa surrounding ulcers in both diseases. This is subverted in ulcerative colitis and preserved in Crohn's colitis.

Original languageEnglish
Pages (from-to)1279-1294
Number of pages16
JournalScanning Electron Microscopy
Volumev
Publication statusPublished - Sep 1985

ASJC Scopus subject areas

  • Biophysics
  • Control and Systems Engineering

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    Bonvicini, F., Zoli, G., Maltarello, M. C., Bianchi, D., Pasquinelli, G., Versura, P., Gasbarrini, G., & Laschi, R. (1985). CLINICAL APPLICATIONS OF SCANNING ELECTRON MICROSCOPY IN GASTROINTESTINAL DISEASES. Scanning Electron Microscopy, v, 1279-1294.