Clinical aspects and management of hereditary non-polyposis colorectal cancer (HNPCC)

Lucio Bertario, Hugo Aste, Arrigo Arrigoni, Pierluigi Fracasso, Francesco Paolo Rossini, Carlo Rossetti, Rosa Valanzano

Research output: Contribution to journalArticle

Abstract

Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal dominant transmitted disease phenotypically defined according to the 'Amsterdam criteria' as follows: at least 3 affected relatives, one of whom first degree relative of other two, at least two successive generations affected. Important cardinal features are: 1 prevalent proximal location of cancers (above splenic flexure); 2 multiple synchronous or methachronous large bowel cancers; 3 early age of onset (

Original languageEnglish
Pages (from-to)117-121
Number of pages5
JournalTumori
Volume82
Issue number2
Publication statusPublished - Mar 1996

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Keywords

  • colorectal cancer
  • HNPCC
  • screening

ASJC Scopus subject areas

  • Cancer Research

Cite this

Bertario, L., Aste, H., Arrigoni, A., Fracasso, P., Rossini, F. P., Rossetti, C., & Valanzano, R. (1996). Clinical aspects and management of hereditary non-polyposis colorectal cancer (HNPCC). Tumori, 82(2), 117-121.