Clinical aspects and management of Hodgkin's disease and other tumours in HIV-infected individuals

E. Vaccher, M. Spina, U. Tirelli

Research output: Contribution to journalArticle

Abstract

As the AIDS epidemic advances, the spectrum of malignancies encountered is expanding. Several non-AIDS defining cancers, i.e. Hodgkin's disease (HD), anal and testicular cancer, are increasing in incidence in HIV-infected patients. The widespread use of highly active antiretroviral therapy (HAART) in industrialised countries has resulted in substantial improvement in the survival of HIV-infected patients. It is likely that in the future, cancers associated with long-term mild immune suppression will occur at an increased rate in long-term survivors of HIV infection. The natural history of the majority of non-AIDS defining tumours differs from that of the general population. Unusual aspects of tumour localisation, growth behaviour and therapeutical responses distinguish tumours in patients with HIV infection from those without. This paper reviews the most relevant data on the epidemiology, pathology, clinical features and treatment of the most frequently reported non-AIDS defining tumours, i.e. HD, lung, testicular and skin cancers.

Original languageEnglish
Pages (from-to)1306-1315
Number of pages10
JournalEuropean Journal of Cancer
Volume37
Issue number10
DOIs
Publication statusPublished - 2001

Keywords

  • HIV
  • Hodgkin's disease
  • Lung cancer
  • Non AIDS-defining tumours
  • Skin cancer
  • Testicular germ cell cancer

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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