Clinical aspects of fatigue in multiple sclerosis

Roberto Bergamaschi, Alfredo Romani, Maurizio Versino, Roberto Poli, Vittorio Cosi

Research output: Contribution to journalArticlepeer-review


We studied 100 multiple sclerosis outpatients in order to assess the frequency of fatigue and to detect its relationships with other clinical findings. Fatigue was quantified by fatigue severity scale (FSS; range 1-7); current clinical neurological status and disability level were respectively scored by Kurtzke's functional systems and expanded disability status scale (EDSS). FSS mean score was 4.12; fatigue was totally absent in 3% of the patients. Fatigue started before onset of the disease in 7 patients, at onset in 12 and within the first year in 7. Fatigue intensity and frequency were related to each other. FSS mean scores were significantly higher in the patients with fatigue worsened by heat (p

Original languageEnglish
Pages (from-to)247-251
Number of pages5
JournalFunctional Neurology
Issue number5
Publication statusPublished - Sep 1997


  • Fatigue
  • Impairment
  • Multiple sclerosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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