Clinical, biochemical and histological abnormalities in adult celiac patients on gluten-free diet

M. T. Bardella, N. Molteni, M. Quatrini, P. Velio, T. Ranzi, P. A. Bianchi

Research output: Contribution to journalArticle

Abstract

Twenty-six adult patients with histologically confirmed celiac disease on gluten-free diet after apparent disease remission were reexamined at 4-6 month intervals for a mean period of 55.4 months (range 13-137). Eight patients remained clinically well with normal blood tests. Eighteen patients had clinical or biological abnormalities. Eleven patients reported repeated episodes of meteorism and abdominal pain and/or diarrhea which disappeared in 2 after lactose withdrawal. Iron deficiency and macrocytic anemia were sometimes observed in 5 and 4 patients respectively. Altered plasma calcium, phosphorus and alkaline phosphatase and/or bone densitometry findings were detected in 7 patients. Seventeen patients (12 presenting some of the above findings) agreed to a repeat biopsy: 13 of these showed grade II and 4 grade III abnormalities. Although adult celiac patients may show marked improvement during gluten-free diet, minor clinical disturbances and biochemical abnormalities may still be present.

Original languageEnglish
Pages (from-to)787-789
Number of pages3
JournalGastroenterologie Clinique et Biologique
Volume9
Issue number11
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Gastroenterology

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    Bardella, M. T., Molteni, N., Quatrini, M., Velio, P., Ranzi, T., & Bianchi, P. A. (1985). Clinical, biochemical and histological abnormalities in adult celiac patients on gluten-free diet. Gastroenterologie Clinique et Biologique, 9(11), 787-789.