TY - JOUR
T1 - Clinical characteristics of metabolic associated fatty liver disease (MAFLD) in subjects with myotonic dystrophy type 1 (DM1)
AU - Miele, Luca
AU - Perna, Alessia
AU - Dajko, Marianxhela
AU - Zocco, Maria A.
AU - De Magistris, Antonio
AU - Nicoletti, Tommaso F.
AU - Biolato, Marco
AU - Marrone, Giuseppe
AU - Liguori, Antonio
AU - Maccora, Daria
AU - Valenza, Venanzio
AU - Rossi, Salvatore
AU - Riso, Vittorio
AU - Di Natale, Daniele
AU - Gasbarrini, Antonio
AU - Grieco, Antonio
AU - Silvestri, Gabriella
N1 - Funding Information:
The Authors have no potential conflicts of interest to disclose. LM and GS conceived and designed the study. AP, MAZ, SR, TN, VR, DM and DDN collected data, LM, MD, ADM analyzed the data and, wrote the draft, AG,VV, and AGr reviewed the draft for important intellectual contribution. LM, GS, AG contributed to discussion and reviewed/edited the final version of the manuscript. LM, AGa, AGr, GS are the guarantors of this work and, as such, had full access to all the data of the study and take responsibility for the integrity and accuracy of data. All authors approved the final version of the manuscript.
Publisher Copyright:
© 2020 Editrice Gastroenterologica Italiana S.r.l.
PY - 2021/11
Y1 - 2021/11
N2 - Background: Myotonic dystrophy type 1 (DM1) is a rare inherited neuromuscular disease associated with insulin resistance, and its association with metabolically associated fatty liver disease (MAFLD) has never been explored in prospective studies. The aim of this study was to assess the clinical features of MAFLD in DM1 patients. Methods: We investigated the prevalence and the diagnostic features of MAFLD in a cohort of 29 outpatient fully characterized DM1 patients; afterward, we compared the selected cohort of DM1-MAFLD individuals with a propensity-matched cohort of non-DM1-MAFLD Results: 13/29 (44.83%) DM1 patients received a clinical diagnosis of MAFLD. Compared to DM1 patients with normal liver, DM1-MAFLD individuals showed a higher male prevalence (p = 0.008), BMI (p = 0.014), HOMA score (p = 0.012), and GGT levels (p = 0.050). The statistical comparison showed that the DM1-MAFLD group had a more severe MAFLD according to the FIB4 score than non-DM1-MAFLD patients. This association of a more severe form of liver disease with DM1 remained significant after logistic regression analysis (OR: 6.12, 95% CI 1.44- 26.55).
AB - Background: Myotonic dystrophy type 1 (DM1) is a rare inherited neuromuscular disease associated with insulin resistance, and its association with metabolically associated fatty liver disease (MAFLD) has never been explored in prospective studies. The aim of this study was to assess the clinical features of MAFLD in DM1 patients. Methods: We investigated the prevalence and the diagnostic features of MAFLD in a cohort of 29 outpatient fully characterized DM1 patients; afterward, we compared the selected cohort of DM1-MAFLD individuals with a propensity-matched cohort of non-DM1-MAFLD Results: 13/29 (44.83%) DM1 patients received a clinical diagnosis of MAFLD. Compared to DM1 patients with normal liver, DM1-MAFLD individuals showed a higher male prevalence (p = 0.008), BMI (p = 0.014), HOMA score (p = 0.012), and GGT levels (p = 0.050). The statistical comparison showed that the DM1-MAFLD group had a more severe MAFLD according to the FIB4 score than non-DM1-MAFLD patients. This association of a more severe form of liver disease with DM1 remained significant after logistic regression analysis (OR: 6.12, 95% CI 1.44- 26.55).
KW - Liver tests
KW - MAFLD
KW - Myotonic dystrophy
KW - NAFLD
KW - NASH
KW - Steinert's disease
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U2 - 10.1016/j.dld.2020.12.010
DO - 10.1016/j.dld.2020.12.010
M3 - Article
C2 - 33436321
AN - SCOPUS:85099169996
VL - 53
SP - 1451
EP - 1457
JO - Digestive and Liver Disease
JF - Digestive and Liver Disease
SN - 1590-8658
IS - 11
ER -