Clinical characterization of familial isolated pituitary adenomas

A. F. Daly, M. L. Jaffrain-Rea, A. Ciccarelli, H. Valdes-Socin, V. Rohmer, G. Tamburrano, C. Borson-Chazot, B. Estour, E. Ciccarelli, T. Brue, P. Ferolla, P. Emy, A. Colao, E. De Menis, P. Lecomte, F. Penfornis, B. Delemer, J. Bertherat, J. L. Wémeau, W. De HerderF. Archambeaud, A. Stevenaert, A. Calender, A. Murat, F. Cavagnini, A. Beckers

Research output: Contribution to journalArticle

Abstract

Context: Familial pituitary adenomas occur rarely in the absence of multiple endocrine neoplasia type 1(MEN1)and Carney complex (CNC). Objective: Our objective was to characterize the clinical and genealogical features of non-MEN1/CNC familial isolated pituitary adenomas (FIPA). Design and Setting: We conducted a retrospective study of clinical and genealogical characteristics of FIPA cases and performed a comparison with a sporadic population at 22 university hospitals in Belgium, Italy, France, and The Netherlands. Results: Sixty-four FIPA families including 138 affected individuals were identified [55 prolactinomas, 47 somatotropinomas, 28 nonsecreting adenomas (NS), and eight ACTH-secreting tumors]. Cases were MEN1/PRKAR1A-mutation negative. First-degree relationships predominated (75.6%) among affected individuals. A single tumor phenotype occurred in 30 families (homogeneous), and heterogeneous phenotypes occurred in 34 families. FIPA cases were younger at diagnosis than sporadic cases (P = 0.015); tumors were diagnosed earlier in the first vs. the second generation of multigenerational families. Macroadenomas were more frequent in heterogeneous vs. homogeneous FIPA families (P = 0.036). Prolactinomas from heterogeneous families were larger and had more frequent suprasellar extension (P = 0.004) than sporadic cases. Somatotropinomas occurred as isolated familial somatotropinoma cases and within heterogeneous FIPA families; isolated familial somatotropinoma cases represented 18% of FIPA cases and were younger at diagnosis than patients with sporadic somatotropinomas. Familial NS cases were younger at diagnosis (P = 0.03) and had more frequently invasive tumors (P = 0.024) than sporadic cases. Conclusions: Homogeneous and heterogeneous expression of prolactinomas, somatotropinomas, NS, and Cushing's disease can occur within families in the absence of MEN1/CNC. FIPA and sporadic cases have differing clinical characteristics. FIPA may represent a novel endocrine neoplasia classification that requires further genetic characterization.

Original languageEnglish
Pages (from-to)3316-3323
Number of pages8
JournalJournal of Clinical Endocrinology and Metabolism
Volume91
Issue number9
DOIs
Publication statusPublished - 2006

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

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    Daly, A. F., Jaffrain-Rea, M. L., Ciccarelli, A., Valdes-Socin, H., Rohmer, V., Tamburrano, G., Borson-Chazot, C., Estour, B., Ciccarelli, E., Brue, T., Ferolla, P., Emy, P., Colao, A., De Menis, E., Lecomte, P., Penfornis, F., Delemer, B., Bertherat, J., Wémeau, J. L., ... Beckers, A. (2006). Clinical characterization of familial isolated pituitary adenomas. Journal of Clinical Endocrinology and Metabolism, 91(9), 3316-3323. https://doi.org/10.1210/jc.2005-2671