Abstract
Introduction Bipolar disorder (BD) is a chronic, highly disabling condition associated with psychiatric/medical comorbidity and substantive morbidity, mortality, and suicide risks. In prior reports, varying parameters have been associated with suicide risk.Objectives To evaluate sociodemographic and clinical variables characterizing Italian individuals with BD with versus without prior suicide attempt (PSA).Methods A sample of 362 Italian patients categorized as BD according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM IV-TR) was assessed and divided in 2 subgroups: with and without PSA. Sociodemographic and clinical variables were compared between prior attempters and non-attempters using corrected multivariate analysis of variance (MANOVA).Results More than one-fourth of BD patients (26.2%) had a PSA, with approximately one-third (31%) of these having>1 PSA. Depressive polarity at onset, higher number of psychiatric hospitalizations, comorbid alcohol abuse, comorbid eating disorders, and psychiatric poly-comorbidity were significantly more frequent (p<.05) in patients with versus without PSA. Additionally, treatment with lithium, polypharmacotherapy (≥4 current drugs) and previous psychosocial rehabilitation were significantly more often present in patients with versus without PSA.Conclusions We found several clinical variables associated with PSA in BD patients. Even though these retrospective findings did not address causality, they could be clinically relevant to better understanding suicidal behavior in BD and adopting proper strategies to prevent suicide in higher risk patients.
| Original language | English |
|---|---|
| Pages (from-to) | 271-277 |
| Number of pages | 7 |
| Journal | CNS Spectrums |
| Volume | 23 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Aug 1 2018 |
Fingerprint
Keywords
- Bipolar disorder
- Clinical characterization
- Pharmacological treatment
- Prior suicide attempt
- Suicide
ASJC Scopus subject areas
- Clinical Neurology
- Psychiatry and Mental health
Cite this
Clinical characterization of Italian suicide attempters with bipolar disorder. / Dell'osso, Bernardo; Vismara, Matteo; Dobrea, Cristina; Cremaschi, Laura; Grancini, Benedetta; Arici, Chiara; Benatti, Beatrice; Buoli, Massimiliano; Ketter, Terence A.; Altamura, A. Carlo.
In: CNS Spectrums, Vol. 23, No. 4, 01.08.2018, p. 271-277.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clinical characterization of Italian suicide attempters with bipolar disorder
AU - Dell'osso, Bernardo
AU - Vismara, Matteo
AU - Dobrea, Cristina
AU - Cremaschi, Laura
AU - Grancini, Benedetta
AU - Arici, Chiara
AU - Benatti, Beatrice
AU - Buoli, Massimiliano
AU - Ketter, Terence A.
AU - Altamura, A. Carlo
PY - 2018/8/1
Y1 - 2018/8/1
N2 - Introduction Bipolar disorder (BD) is a chronic, highly disabling condition associated with psychiatric/medical comorbidity and substantive morbidity, mortality, and suicide risks. In prior reports, varying parameters have been associated with suicide risk.Objectives To evaluate sociodemographic and clinical variables characterizing Italian individuals with BD with versus without prior suicide attempt (PSA).Methods A sample of 362 Italian patients categorized as BD according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM IV-TR) was assessed and divided in 2 subgroups: with and without PSA. Sociodemographic and clinical variables were compared between prior attempters and non-attempters using corrected multivariate analysis of variance (MANOVA).Results More than one-fourth of BD patients (26.2%) had a PSA, with approximately one-third (31%) of these having>1 PSA. Depressive polarity at onset, higher number of psychiatric hospitalizations, comorbid alcohol abuse, comorbid eating disorders, and psychiatric poly-comorbidity were significantly more frequent (p<.05) in patients with versus without PSA. Additionally, treatment with lithium, polypharmacotherapy (≥4 current drugs) and previous psychosocial rehabilitation were significantly more often present in patients with versus without PSA.Conclusions We found several clinical variables associated with PSA in BD patients. Even though these retrospective findings did not address causality, they could be clinically relevant to better understanding suicidal behavior in BD and adopting proper strategies to prevent suicide in higher risk patients.
AB - Introduction Bipolar disorder (BD) is a chronic, highly disabling condition associated with psychiatric/medical comorbidity and substantive morbidity, mortality, and suicide risks. In prior reports, varying parameters have been associated with suicide risk.Objectives To evaluate sociodemographic and clinical variables characterizing Italian individuals with BD with versus without prior suicide attempt (PSA).Methods A sample of 362 Italian patients categorized as BD according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM IV-TR) was assessed and divided in 2 subgroups: with and without PSA. Sociodemographic and clinical variables were compared between prior attempters and non-attempters using corrected multivariate analysis of variance (MANOVA).Results More than one-fourth of BD patients (26.2%) had a PSA, with approximately one-third (31%) of these having>1 PSA. Depressive polarity at onset, higher number of psychiatric hospitalizations, comorbid alcohol abuse, comorbid eating disorders, and psychiatric poly-comorbidity were significantly more frequent (p<.05) in patients with versus without PSA. Additionally, treatment with lithium, polypharmacotherapy (≥4 current drugs) and previous psychosocial rehabilitation were significantly more often present in patients with versus without PSA.Conclusions We found several clinical variables associated with PSA in BD patients. Even though these retrospective findings did not address causality, they could be clinically relevant to better understanding suicidal behavior in BD and adopting proper strategies to prevent suicide in higher risk patients.
KW - Bipolar disorder
KW - Clinical characterization
KW - Pharmacological treatment
KW - Prior suicide attempt
KW - Suicide
UR - http://www.scopus.com/inward/record.url?scp=85021111651&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85021111651&partnerID=8YFLogxK
U2 - 10.1017/S1092852917000384
DO - 10.1017/S1092852917000384
M3 - Article
VL - 23
SP - 271
EP - 277
JO - CNS Spectrums
JF - CNS Spectrums
SN - 1092-8529
IS - 4
ER -