Clinical classification and survival in chronic lymphocytic leukemia

A. Santoro, R. Musumeci, F. Rilke, F. Franchi, P. Valagussa, E. Bajetta, S. Monfardini

Research output: Contribution to journalArticle


61 consecutive patients with chronic lymphocytic leukemia (CLL) were classified according to the staging system of Rai et al. Analysis of this series showed the following median survival (in months) from diagnosis: Stage 0-I, 73; stage II, 44; stage III-IV, 32. In 11 patients without peripheral palpable adenopathies, the lymphangiogram showed abnormal retroperitoneal lymph nodes. Therefore, the initial stage was changed from 0 to I in 5 cases. The median survival for the entire series was 50 months. Patients with 'indolent' disease had a median survival of 52 mnth, while in patients with 'active' CLL, the median survival was 32 mnth. Both sex and age were shown to be poor predictors of survival. Increased duration of survival was observed in patients with less compared to those with more than 30,000 lymphocytes/mm 3 (66 versus 41 mnth). This method of staging, utilized to classify this series at the time of diagnosis, was confirmed to be a reliable predictor for survival.

Original languageEnglish
Pages (from-to)39-49
Number of pages11
Issue number1
Publication statusPublished - 1979

ASJC Scopus subject areas

  • Cancer Research

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    Santoro, A., Musumeci, R., Rilke, F., Franchi, F., Valagussa, P., Bajetta, E., & Monfardini, S. (1979). Clinical classification and survival in chronic lymphocytic leukemia. Tumori, 65(1), 39-49.