Clinical Complications and Their Management

Alessia Marcon, Irene Motta, Ali T. Taher, Maria Domenica Cappellini

Research output: Contribution to journalReview articlepeer-review


The hallmarks of thalassemias are ineffective erythropoiesis and peripheral hemolysis leading to a cascade of events responsible for several clinical complications. This pathophysiologic mechanism can be partially controlled by blood transfusions or by correction of the severity of ineffective erythropoiesis. Thalassemias include a spectrum of phenotypes. Two main groups can be clinically distinguished: transfusion-dependent (TDT) and non–transfusion-dependent (NTDT) thalassemia. Both conditions are characterized by several clinical complications along life; some are shared, whereas some have higher prevalence in one group over the other. The authors present the most common clinical complications in TDT and NTDT and their management.

Original languageEnglish
Pages (from-to)223-236
Number of pages14
JournalHematology/Oncology Clinics of North America
Issue number2
Publication statusPublished - Apr 1 2018


  • Endocrinopathies
  • Heart failure
  • Ineffective erythropoiesis
  • Iron overload
  • Liver disease
  • Thalassemia

ASJC Scopus subject areas

  • Hematology
  • Oncology


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