Clinical correlate and fine specificity of anti-GQ1b antibodies in peripheral neuropathy

Marinella Carpo, Rosetta Pedotti, Francesco Lolli, Anita Pitrola, Silvia Allaria, Guglielmo Scarlato, Eduardo Nobile-Orazio

Research output: Contribution to journalArticlepeer-review

Abstract

We studied the frequency, fine specificity and clinical correlate of anti-GQ1b IgG and IgM antibodies in 216 patients with neuropathy including three with Miller Fisher syndrome (MFS), 73 with Guillain-Barre syndrome (GBS), 99 with neuropathy associated with IgM monoclonal gammopathy (PN+IgM) and 41 with other neuropathies, and compared the data with 92 disease or normal controls. We found high (>1/100) anti-GQ1b IgG titers in all three MFS patients and in two GBS patients (2.7%) with ophthalmoplegia and ataxia, while high anti-GQ1b IgM were only found in two patients with a chronic demyelinating sensorimotor neuropathy associated with IgMκ monoclonal gammopathy (2%). By overlay HPTLC, IgG antibodies in MFS and GBS either selectively reacted with GQ1b or also bound to GD3, and less intensely to GD1b, while IgM antibodies from both patients with PN+IgM also strongly reacted with GD1b and, in one, with GD3 and GT1b. The constant association of anti-GQ1b antibodies with dysimmune neuropathies and the correlation between their isotype, fine specificity and clinical presentation, support a possible pathogenetic link between these antibodies and the neuropathy.

Original languageEnglish
Pages (from-to)186-191
Number of pages6
JournalJournal of the Neurological Sciences
Volume155
Issue number2
DOIs
Publication statusPublished - Mar 5 1998

Keywords

  • Antibodies
  • Gangliosides
  • GQ1b
  • Guillain-Barre syndrome
  • Miller Fisher syndrome
  • Neuropathy

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Surgery
  • Neuroscience(all)
  • Developmental Neuroscience
  • Neurology

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