Clinical correlates and cognitive underpinnings of verbal fluency impairment after chronic subthalamic stimulation in Parkinson's disease

D. De Gaspari, C. Siri, M. Di Gioia, A. Antonini, V. Isella, A. Pizzolato, A. Landi, F. Vergani, S. M. Gaini, I. M. Appollonio, G. Pezzoli

Research output: Contribution to journalArticlepeer-review

Abstract

A decline in verbal fluency is the most consistent neuropsychological sequela of deep brain stimulation (DBS) for Parkinson's disease. We assessed clinical correlates and switching and clustering subcomponents in 26 parkinsonians undergoing subthalamic DBS. Post-surgical motor improvement was accompanied by worsening at both letter and category fluency tasks. Total number of words and switches decreased, while average cluster size was unchanged. Worsening tended to be prominent in patients with baseline poorer cognitive status and more depressed mood. Impairment of shifting suggests prefrontal dysfunction, possibly due to disruption of fronto-striatal circuits along the surgical trajectory and/or to high frequency stimulation itself.

Original languageEnglish
Pages (from-to)289-295
Number of pages7
JournalParkinsonism and Related Disorders
Volume12
Issue number5
DOIs
Publication statusPublished - Jun 2006

Keywords

  • Clustering and switching
  • Deep brain stimulation
  • Parkinson's disease
  • Verbal fluency

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Neurology

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