Clinical correlation among male infertility and overall male health: A systematic review of the literature: Investigative and Clinical Urology

F. Del Giudice, A.M. Kasman, M. Ferro, A. Sciarra, E. De Berardinis, F. Belladelli, A. Salonia, M.L. Eisenberg

Research output: Contribution to journalArticlepeer-review


Purpose: Ongoing evidence has suggested the role of male factor infertility as a potential predictor of mortality and general health status. The aim of the present review is to update the current knowledge base regarding the association between male factor infertility and general health through a critical review of the literature. Materials and Methods: A systematic review of the literature was carried out from inception to November 2019 in order to evaluate significant associations between male infertility and adverse health outcomes such as cardiovascular, oncologic, metabolic and autoimmune diseases as well as overall mortality. Results: In all, 27 studies met inclusion criteria and were critically examined. Five studies examined male infertility and cardiovascular disease risk, 11 examined oncologic risk (e.g., overall cancer risk, testis and prostate cancer), 8 examined aggregate chronic medical diseases and 5 infertility related to incidence of mortality, for a total of 599,807 men diagnosed with any male factor infertility covering a period from 1916 to 2016. Conclusions: A man’s fertility and overall health appear to be interconnected. Therefore, a diagnosis of male infertility may allow a window into future comorbidity and/or mortality which may help guide clinical decisions and counseling. Several possible etiologies such as genetic, epigenetic, developmental, and lifestyle-based factors need to be further evaluated in order to establish the underlying mechanisms between male infertility and health. © The Korean Urological Association.
Original languageEnglish
Pages (from-to)355-371
Number of pages17
JournalInvestig. Clin. Urol.
Issue number4
Publication statusPublished - 2020


  • Androgens
  • Health
  • Hypogonadism
  • Infertility, male
  • Mortality
  • androgen
  • DNA mismatch repair protein MSH2
  • excision repair cross complementing protein 1
  • MutL protein homolog 1
  • adverse outcome
  • Article
  • autoimmune disease
  • azoospermia
  • cancer risk
  • cardiovascular disease
  • cardiovascular risk
  • comorbidity
  • epigenetics
  • genetics
  • health
  • heart failure
  • hereditary nonpolyposis colorectal cancer
  • human
  • hypertension
  • hypogonadism
  • in vitro fertilization
  • infertility therapy
  • insulin resistance
  • intracytoplasmic sperm injection
  • ischemic heart disease
  • lifestyle
  • male
  • male infertility
  • metabolic disorder
  • mortality
  • obesity
  • oligospermia
  • overall survival
  • prostate cancer
  • quality control
  • rheumatoid arthritis
  • sperm quality
  • spermatogenesis
  • spermatozoon count
  • systematic review
  • systemic lupus erythematosus
  • testis cancer
  • thyroiditis
  • varicocele
  • vasectomy


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