Clinical Correlations of α2,6-Sialyltransferase Expression in Colorectal Cancer Patients

Mario Lise, Claudio Belluco, Sauni P. Perera, Rupal Patel, Peter Thomas, Aniruddha Ganguly

Research output: Contribution to journalArticle

Abstract

We have previously demonstrated a link between α2,6-Sialyltransferase (α2,6-ST; E.C. 2.4.99.1) expression and differentiation of colon tumors. So far, information is not available relative to the expression of α2,6-ST in tumors and the survival of patients with colorectal cancer. We have examined the expression of α2,6-ST in a variety of colorectal adenocarcinomas (n = 46) at different stages of differentiation (G1 to G3) by immunoperoxidase assay using monoclonal antibody (MAb) 6B9. Clinical outcome of the patients in a 5-year follow-up study has been correlated with the expression of α2,6-ST in tumors surgically removed from the same patients. No significant difference in the α2,6-ST expression was noted when age, sex, and tumor locations (colon, rectum) were included as parameters. However, 52% of the moderate (G2) and well-differentiated (G1) adenocarcinomas showed stronger α2,6-ST expression compared with poorly differentiated (G3) adenocarcinomas. Notably, absence to moderate levels of tumor α2,6-ST expression was correlated with 100% survival in patients with stage I and II tumors compared with 64% survival in patients with strong tumor α2,6-ST expression (p <0.01). These studies suggest a negative correlation between the expression of α2,6-ST in tumors and a good clinical outcome in colorectal cancer patients.

Original languageEnglish
Pages (from-to)281-286
Number of pages6
JournalHybridoma
Volume19
Issue number4
Publication statusPublished - 2000

ASJC Scopus subject areas

  • Genetics
  • Immunology

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    Lise, M., Belluco, C., Perera, S. P., Patel, R., Thomas, P., & Ganguly, A. (2000). Clinical Correlations of α2,6-Sialyltransferase Expression in Colorectal Cancer Patients. Hybridoma, 19(4), 281-286.