TY - JOUR
T1 - Clinical correlations of genetic changes by comparative genomic hybridization in Ewing sarcoma and related tumors
AU - Tarkkanen, M.
AU - Kiuru-Kuhlefelt, S.
AU - Blomqvist, C.
AU - Armengol, G.
AU - Böhling, T.
AU - Ekfors, T.
AU - Virolainen, M.
AU - Lindholm, P.
AU - Monge, O.
AU - Picci, P.
AU - Knuutila, S.
AU - Elomaa, I.
PY - 1999/10/1
Y1 - 1999/10/1
N2 - Our previous comparative genomic hybridization (CGH) study of Ewing sarcoma and related tumors showed that DNA sequence copy number increases of 1q21~q22 and of chromosomes 8 and 12 were associated with trends toward poor survival (Armengol et al., Br J Cancer 1997, 75, 1403-1409). These trends were not statistically significant. In the present study, we analyzed 28 primary Ewing sarcomas and related tumors by CGH to study whether these (or other) changes have prognostic value in these tumors. Twenty-one tumors (75%) had changes with a mean of 1.9 changes per tumor. The most frequent aberration was gain of chromosome 8 in 10 tumors (36%). Five tumors (18%) had copy number increases at 1q21~22 and 5 had gain of 7q. Copy number increase of 6p21.1~pter, gain of chromosome 12, and loss of 16q were seen in 11%. Copy number increases of 1q21~q22 and of chromosomes 8 and 12 were associated with trends toward worse outcome, but the differences did not reach statistical significance. A novel finding is the association of copy number increase at 6p with worse distant disease-free (P = 0.04) and overall survival (P = 0.004). To confirm this finding and to see whether copy number increases of 1q21~q22 and of chromosomes 8 and 12 have definite prognostic value, a larger number of cases needs to be studied.
AB - Our previous comparative genomic hybridization (CGH) study of Ewing sarcoma and related tumors showed that DNA sequence copy number increases of 1q21~q22 and of chromosomes 8 and 12 were associated with trends toward poor survival (Armengol et al., Br J Cancer 1997, 75, 1403-1409). These trends were not statistically significant. In the present study, we analyzed 28 primary Ewing sarcomas and related tumors by CGH to study whether these (or other) changes have prognostic value in these tumors. Twenty-one tumors (75%) had changes with a mean of 1.9 changes per tumor. The most frequent aberration was gain of chromosome 8 in 10 tumors (36%). Five tumors (18%) had copy number increases at 1q21~22 and 5 had gain of 7q. Copy number increase of 6p21.1~pter, gain of chromosome 12, and loss of 16q were seen in 11%. Copy number increases of 1q21~q22 and of chromosomes 8 and 12 were associated with trends toward worse outcome, but the differences did not reach statistical significance. A novel finding is the association of copy number increase at 6p with worse distant disease-free (P = 0.04) and overall survival (P = 0.004). To confirm this finding and to see whether copy number increases of 1q21~q22 and of chromosomes 8 and 12 have definite prognostic value, a larger number of cases needs to be studied.
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U2 - 10.1016/S0165-4608(99)00031-X
DO - 10.1016/S0165-4608(99)00031-X
M3 - Article
C2 - 10526533
AN - SCOPUS:0032875228
VL - 114
SP - 35
EP - 41
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
SN - 0165-4608
IS - 1
ER -