Clinical course and variability of non-Rasmussen, nonstroke motor and sensory epilepsia partialis continua: A European survey and analysis of 65 cases

Ruta Mameniskiene, Thomas Bast, Carla Bentes, Maria P. Canevini, Petia Dimova, Tiziana Granata, Hans Høgenhaven, Bosanka Jocic Jakubi, Petr Marusic, Gayane Melikyan, Roberto Michelucci, Konstantin Y. Mukhin, Bernhard Oehl, Francesca Ragona, Andrea O. Rossetti, Guido Rubboli, Susanne Schubert, Ulrich Stephani, Julia Strobel, Aglaia VignoliJana Zarubova, Peter Wolf

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Purpose: To gain new insights into the clinical presentation, causes, treatment and prognosis of epilepsia partialis continua (EPC), and to develop hypotheses to be tested in a prospective investigation. Methods: In this retrospective multicenter study, all cases were included that fulfilled these criteria: constantly repeated fragments of epileptic seizures, with preserved consciousness, lasting ≥1 h and representing locally restricted motor or sensory epileptic activity. Single episodes were included when they lasted for a minimum of 1 day. EPC with Rasmussen syndrome and acute stroke were excluded. Key Findings: Three time courses with two subtypes each were distinguished, that is, EPC as a solitary event (de novo or in preexistent epilepsy); chronic repetitive nonprogressive EPC (with frequent or rare episodes); and chronic persistent nonprogressive EPC (primarily or evolving out of an episodic course). These were unrelated to etiologies (morphologic lesions 34%, inflammatory 29%, systemic disorders 9%, idiopathic 5%, unknown 23%). Precipitation and inhibition of seizures is a frequent feature of EPC. Levetiracetam and topiramate have improved the possibilities for pharmacotherapy. Topiramate seems to be particularly effective with dysontogenetic etiologies. Significance: The existence of several clearly distinct courses of nonprogressive EPC is a new finding. These distinctions will be further investigated in a prospective study with precise protocols for electroencephalography (EEG), imaging, and other studies. This should better establish the relation of motor and somatosensory EPC; further clarify the relations, pathogenesis, and significance of the different types and their etiologies; and possibly identify more semiologic variants. It should also provide more precise knowledge about therapy and modification of ictogenesis by external stimuli.

Original languageEnglish
Pages (from-to)1168-1176
Number of pages9
JournalEpilepsia
Volume52
Issue number6
DOIs
Publication statusPublished - Jun 2011

Fingerprint

Epilepsia Partialis Continua
etiracetam
Epilepsy
Surveys and Questionnaires
Encephalitis
Consciousness
Multicenter Studies
Electroencephalography
Seizures
Retrospective Studies
Stroke
Prospective Studies
Drug Therapy

Keywords

  • Aura continua
  • Developments of epilepsia partialis continua
  • Epilepsia partialis continua etiologies
  • Focal status epilepticus
  • Nonprogressive epilepsia partialis continua
  • Sensory epilepsia partialis continua

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Clinical course and variability of non-Rasmussen, nonstroke motor and sensory epilepsia partialis continua : A European survey and analysis of 65 cases. / Mameniskiene, Ruta; Bast, Thomas; Bentes, Carla; Canevini, Maria P.; Dimova, Petia; Granata, Tiziana; Høgenhaven, Hans; Jakubi, Bosanka Jocic; Marusic, Petr; Melikyan, Gayane; Michelucci, Roberto; Mukhin, Konstantin Y.; Oehl, Bernhard; Ragona, Francesca; Rossetti, Andrea O.; Rubboli, Guido; Schubert, Susanne; Stephani, Ulrich; Strobel, Julia; Vignoli, Aglaia; Zarubova, Jana; Wolf, Peter.

In: Epilepsia, Vol. 52, No. 6, 06.2011, p. 1168-1176.

Research output: Contribution to journalArticle

Mameniskiene, R, Bast, T, Bentes, C, Canevini, MP, Dimova, P, Granata, T, Høgenhaven, H, Jakubi, BJ, Marusic, P, Melikyan, G, Michelucci, R, Mukhin, KY, Oehl, B, Ragona, F, Rossetti, AO, Rubboli, G, Schubert, S, Stephani, U, Strobel, J, Vignoli, A, Zarubova, J & Wolf, P 2011, 'Clinical course and variability of non-Rasmussen, nonstroke motor and sensory epilepsia partialis continua: A European survey and analysis of 65 cases', Epilepsia, vol. 52, no. 6, pp. 1168-1176. https://doi.org/10.1111/j.1528-1167.2010.02974.x
Mameniskiene, Ruta ; Bast, Thomas ; Bentes, Carla ; Canevini, Maria P. ; Dimova, Petia ; Granata, Tiziana ; Høgenhaven, Hans ; Jakubi, Bosanka Jocic ; Marusic, Petr ; Melikyan, Gayane ; Michelucci, Roberto ; Mukhin, Konstantin Y. ; Oehl, Bernhard ; Ragona, Francesca ; Rossetti, Andrea O. ; Rubboli, Guido ; Schubert, Susanne ; Stephani, Ulrich ; Strobel, Julia ; Vignoli, Aglaia ; Zarubova, Jana ; Wolf, Peter. / Clinical course and variability of non-Rasmussen, nonstroke motor and sensory epilepsia partialis continua : A European survey and analysis of 65 cases. In: Epilepsia. 2011 ; Vol. 52, No. 6. pp. 1168-1176.
@article{0d7bca3717a84d5b9155ad789d0a0ec8,
title = "Clinical course and variability of non-Rasmussen, nonstroke motor and sensory epilepsia partialis continua: A European survey and analysis of 65 cases",
abstract = "Purpose: To gain new insights into the clinical presentation, causes, treatment and prognosis of epilepsia partialis continua (EPC), and to develop hypotheses to be tested in a prospective investigation. Methods: In this retrospective multicenter study, all cases were included that fulfilled these criteria: constantly repeated fragments of epileptic seizures, with preserved consciousness, lasting ≥1 h and representing locally restricted motor or sensory epileptic activity. Single episodes were included when they lasted for a minimum of 1 day. EPC with Rasmussen syndrome and acute stroke were excluded. Key Findings: Three time courses with two subtypes each were distinguished, that is, EPC as a solitary event (de novo or in preexistent epilepsy); chronic repetitive nonprogressive EPC (with frequent or rare episodes); and chronic persistent nonprogressive EPC (primarily or evolving out of an episodic course). These were unrelated to etiologies (morphologic lesions 34{\%}, inflammatory 29{\%}, systemic disorders 9{\%}, idiopathic 5{\%}, unknown 23{\%}). Precipitation and inhibition of seizures is a frequent feature of EPC. Levetiracetam and topiramate have improved the possibilities for pharmacotherapy. Topiramate seems to be particularly effective with dysontogenetic etiologies. Significance: The existence of several clearly distinct courses of nonprogressive EPC is a new finding. These distinctions will be further investigated in a prospective study with precise protocols for electroencephalography (EEG), imaging, and other studies. This should better establish the relation of motor and somatosensory EPC; further clarify the relations, pathogenesis, and significance of the different types and their etiologies; and possibly identify more semiologic variants. It should also provide more precise knowledge about therapy and modification of ictogenesis by external stimuli.",
keywords = "Aura continua, Developments of epilepsia partialis continua, Epilepsia partialis continua etiologies, Focal status epilepticus, Nonprogressive epilepsia partialis continua, Sensory epilepsia partialis continua",
author = "Ruta Mameniskiene and Thomas Bast and Carla Bentes and Canevini, {Maria P.} and Petia Dimova and Tiziana Granata and Hans H{\o}genhaven and Jakubi, {Bosanka Jocic} and Petr Marusic and Gayane Melikyan and Roberto Michelucci and Mukhin, {Konstantin Y.} and Bernhard Oehl and Francesca Ragona and Rossetti, {Andrea O.} and Guido Rubboli and Susanne Schubert and Ulrich Stephani and Julia Strobel and Aglaia Vignoli and Jana Zarubova and Peter Wolf",
year = "2011",
month = "6",
doi = "10.1111/j.1528-1167.2010.02974.x",
language = "English",
volume = "52",
pages = "1168--1176",
journal = "Epilepsia",
issn = "0013-9580",
publisher = "Blackwell Publishing Inc.",
number = "6",

}

TY - JOUR

T1 - Clinical course and variability of non-Rasmussen, nonstroke motor and sensory epilepsia partialis continua

T2 - A European survey and analysis of 65 cases

AU - Mameniskiene, Ruta

AU - Bast, Thomas

AU - Bentes, Carla

AU - Canevini, Maria P.

AU - Dimova, Petia

AU - Granata, Tiziana

AU - Høgenhaven, Hans

AU - Jakubi, Bosanka Jocic

AU - Marusic, Petr

AU - Melikyan, Gayane

AU - Michelucci, Roberto

AU - Mukhin, Konstantin Y.

AU - Oehl, Bernhard

AU - Ragona, Francesca

AU - Rossetti, Andrea O.

AU - Rubboli, Guido

AU - Schubert, Susanne

AU - Stephani, Ulrich

AU - Strobel, Julia

AU - Vignoli, Aglaia

AU - Zarubova, Jana

AU - Wolf, Peter

PY - 2011/6

Y1 - 2011/6

N2 - Purpose: To gain new insights into the clinical presentation, causes, treatment and prognosis of epilepsia partialis continua (EPC), and to develop hypotheses to be tested in a prospective investigation. Methods: In this retrospective multicenter study, all cases were included that fulfilled these criteria: constantly repeated fragments of epileptic seizures, with preserved consciousness, lasting ≥1 h and representing locally restricted motor or sensory epileptic activity. Single episodes were included when they lasted for a minimum of 1 day. EPC with Rasmussen syndrome and acute stroke were excluded. Key Findings: Three time courses with two subtypes each were distinguished, that is, EPC as a solitary event (de novo or in preexistent epilepsy); chronic repetitive nonprogressive EPC (with frequent or rare episodes); and chronic persistent nonprogressive EPC (primarily or evolving out of an episodic course). These were unrelated to etiologies (morphologic lesions 34%, inflammatory 29%, systemic disorders 9%, idiopathic 5%, unknown 23%). Precipitation and inhibition of seizures is a frequent feature of EPC. Levetiracetam and topiramate have improved the possibilities for pharmacotherapy. Topiramate seems to be particularly effective with dysontogenetic etiologies. Significance: The existence of several clearly distinct courses of nonprogressive EPC is a new finding. These distinctions will be further investigated in a prospective study with precise protocols for electroencephalography (EEG), imaging, and other studies. This should better establish the relation of motor and somatosensory EPC; further clarify the relations, pathogenesis, and significance of the different types and their etiologies; and possibly identify more semiologic variants. It should also provide more precise knowledge about therapy and modification of ictogenesis by external stimuli.

AB - Purpose: To gain new insights into the clinical presentation, causes, treatment and prognosis of epilepsia partialis continua (EPC), and to develop hypotheses to be tested in a prospective investigation. Methods: In this retrospective multicenter study, all cases were included that fulfilled these criteria: constantly repeated fragments of epileptic seizures, with preserved consciousness, lasting ≥1 h and representing locally restricted motor or sensory epileptic activity. Single episodes were included when they lasted for a minimum of 1 day. EPC with Rasmussen syndrome and acute stroke were excluded. Key Findings: Three time courses with two subtypes each were distinguished, that is, EPC as a solitary event (de novo or in preexistent epilepsy); chronic repetitive nonprogressive EPC (with frequent or rare episodes); and chronic persistent nonprogressive EPC (primarily or evolving out of an episodic course). These were unrelated to etiologies (morphologic lesions 34%, inflammatory 29%, systemic disorders 9%, idiopathic 5%, unknown 23%). Precipitation and inhibition of seizures is a frequent feature of EPC. Levetiracetam and topiramate have improved the possibilities for pharmacotherapy. Topiramate seems to be particularly effective with dysontogenetic etiologies. Significance: The existence of several clearly distinct courses of nonprogressive EPC is a new finding. These distinctions will be further investigated in a prospective study with precise protocols for electroencephalography (EEG), imaging, and other studies. This should better establish the relation of motor and somatosensory EPC; further clarify the relations, pathogenesis, and significance of the different types and their etiologies; and possibly identify more semiologic variants. It should also provide more precise knowledge about therapy and modification of ictogenesis by external stimuli.

KW - Aura continua

KW - Developments of epilepsia partialis continua

KW - Epilepsia partialis continua etiologies

KW - Focal status epilepticus

KW - Nonprogressive epilepsia partialis continua

KW - Sensory epilepsia partialis continua

UR - http://www.scopus.com/inward/record.url?scp=79958861318&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79958861318&partnerID=8YFLogxK

U2 - 10.1111/j.1528-1167.2010.02974.x

DO - 10.1111/j.1528-1167.2010.02974.x

M3 - Article

C2 - 21320117

AN - SCOPUS:79958861318

VL - 52

SP - 1168

EP - 1176

JO - Epilepsia

JF - Epilepsia

SN - 0013-9580

IS - 6

ER -