Clinical course of classic Kaposi's sarcoma in HIV-negative patients treated with the HIV protease inhibitor indinavir

Paolo Correction Monini; Cecilia Sgadari; Maria Gabriella Grosso; Stefania Bellino; Antonio Di Biagio; Elena Toschi; Ilaria Bacigalupo; Michela Sabbatucci; Giulia Cencioni; Emanuela Salvi; Patrizia Leone; Barbara Ensoli; G. Barillari; G. Moracci; L. Carratelli; G. Gatti; L. Brambilla; M. Brambati; S. Ferrucci; O. De Pità; M. A. Pilla; A. Di Carlo; M. Giuliani; F. Cottoni; M. A. Cuccuru; S. Calvieri; R. Clerico; C. Potenza; U. Tirelli; C. Simonelli; F. Martellotta; R. Strumia; A. Borghi; S. Del Giacco; L. Moi; G. Piludu; M. C. Sirianni; M. Campagna; L. Sarmati; M. Andreoni; G. Bianchini; J. Sheldon; J. Milzer; T. Schulz

doi:10.1097/QAD.0b013e3283262a8d

Clinical course of classic Kaposi's sarcoma in HIV-negative patients treated with the HIV protease inhibitor indinavir

Paolo Correction Monini, Cecilia Sgadari, Maria Gabriella Grosso, Stefania Bellino, Antonio Di Biagio, Elena Toschi, Ilaria Bacigalupo, Michela Sabbatucci, Giulia Cencioni, Emanuela Salvi, Patrizia Leone, Barbara Ensoli, G. Barillari, G. Moracci, L. Carratelli, G. Gatti, L. Brambilla, M. Brambati, S. Ferrucci, O. De PitàM. A. Pilla, A. Di Carlo, M. Giuliani, F. Cottoni, M. A. Cuccuru, S. Calvieri, R. Clerico, C. Potenza, U. Tirelli, C. Simonelli, F. Martellotta, R. Strumia, A. Borghi, S. Del Giacco, L. Moi, G. Piludu, M. C. Sirianni, M. Campagna, L. Sarmati, M. Andreoni, G. Bianchini, J. Sheldon, J. Milzer, T. Schulz

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Abstract

HIV protease inhibitors have been shown to exert antiangiogenic and antitumor actions independently from their antiretroviral effect. Based on these studies, HIV-seronegative patients with classic Kaposi's sarcoma were treated with indinavir and followed for clinical evolution, drug pharmacokinetics and Kaposi's sarcoma biomarkers. A favorable clinical course was associated with high drug plasma levels, reduced production of basic fibroblast growth factor, lower numbers of circulating endothelial cells, and a decrease in antibody titers against human herpesvirus 8.

Original language	English
Pages (from-to)	534-538
Number of pages	5
Journal	AIDS (London, England)
Volume	23
Issue number	4
DOIs	https://doi.org/10.1097/QAD.0b013e3283262a8d
Publication status	Published - Feb 20 2009

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

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Correction Monini, P., Sgadari, C., Grosso, M. G., Bellino, S., Di Biagio, A., Toschi, E., Bacigalupo, I., Sabbatucci, M., Cencioni, G., Salvi, E., Leone, P., Ensoli, B., Barillari, G., Moracci, G., Carratelli, L., Gatti, G., Brambilla, L., Brambati, M., Ferrucci, S., ... Schulz, T. (2009). Clinical course of classic Kaposi's sarcoma in HIV-negative patients treated with the HIV protease inhibitor indinavir. AIDS (London, England), 23(4), 534-538. https://doi.org/10.1097/QAD.0b013e3283262a8d

Correction Monini, P, Sgadari, C, Grosso, MG, Bellino, S, Di Biagio, A, Toschi, E, Bacigalupo, I, Sabbatucci, M, Cencioni, G, Salvi, E, Leone, P, Ensoli, B, Barillari, G, Moracci, G, Carratelli, L, Gatti, G, Brambilla, L, Brambati, M, Ferrucci, S, De Pità, O, Pilla, MA, Di Carlo, A, Giuliani, M, Cottoni, F, Cuccuru, MA, Calvieri, S, Clerico, R, Potenza, C, Tirelli, U, Simonelli, C, Martellotta, F, Strumia, R, Borghi, A, Del Giacco, S, Moi, L, Piludu, G, Sirianni, MC, Campagna, M, Sarmati, L, Andreoni, M, Bianchini, G, Sheldon, J, Milzer, J & Schulz, T 2009, 'Clinical course of classic Kaposi's sarcoma in HIV-negative patients treated with the HIV protease inhibitor indinavir', AIDS (London, England), vol. 23, no. 4, pp. 534-538. https://doi.org/10.1097/QAD.0b013e3283262a8d

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abstract = "HIV protease inhibitors have been shown to exert antiangiogenic and antitumor actions independently from their antiretroviral effect. Based on these studies, HIV-seronegative patients with classic Kaposi's sarcoma were treated with indinavir and followed for clinical evolution, drug pharmacokinetics and Kaposi's sarcoma biomarkers. A favorable clinical course was associated with high drug plasma levels, reduced production of basic fibroblast growth factor, lower numbers of circulating endothelial cells, and a decrease in antibody titers against human herpesvirus 8.",

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AU - Correction Monini, Paolo

AU - Sgadari, Cecilia

AU - Grosso, Maria Gabriella

AU - Bellino, Stefania

AU - Di Biagio, Antonio

AU - Toschi, Elena

AU - Bacigalupo, Ilaria

AU - Sabbatucci, Michela

AU - Cencioni, Giulia

AU - Salvi, Emanuela

AU - Leone, Patrizia

AU - Ensoli, Barbara

AU - Barillari, G.

AU - Moracci, G.

AU - Carratelli, L.

AU - Gatti, G.

AU - Brambilla, L.

AU - Brambati, M.

AU - Ferrucci, S.

AU - De Pità, O.

AU - Pilla, M. A.

AU - Di Carlo, A.

AU - Giuliani, M.

AU - Cottoni, F.

AU - Cuccuru, M. A.

AU - Calvieri, S.

AU - Clerico, R.

AU - Potenza, C.

AU - Tirelli, U.

AU - Simonelli, C.

AU - Martellotta, F.

AU - Strumia, R.

AU - Borghi, A.

AU - Del Giacco, S.

AU - Moi, L.

AU - Piludu, G.

AU - Sirianni, M. C.

AU - Campagna, M.

AU - Sarmati, L.

AU - Andreoni, M.

AU - Bianchini, G.

AU - Sheldon, J.

AU - Milzer, J.

AU - Schulz, T.

PY - 2009/2/20

Y1 - 2009/2/20

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Clinical course of classic Kaposi's sarcoma in HIV-negative patients treated with the HIV protease inhibitor indinavir

Abstract

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