Clinical dissection of childhood occipital epilepsy of Gastaut and prognostic implication

Alberto Verrotti, Daniela Laino, Victoria Elisa Rinaldi, A. Suppiej, L. Giordano, Irene Toldo, Lucia Margari, P. Parisi, R. Rizzo, Sara Matricardi, Raffaella Cusmai, Salvatore Grosso, R. Gaggero, Nelia Zamponi, P. Pavone, Giuseppe Capovilla, M. Rauchenzauner, C. Cerminara, Giancarlo Di Gennaro, Maria Esposito & 9 others Pasquale Striano, Salvatore Savasta, Giangennaro Coppola, Sabrina Siliquini, Francesca Operto, Vincenzo Belcastro, Francesca Ragona, Gianluigi Marseglia, Alberto Spalice

Research output: Contribution to journalArticle

Abstract

Background and purpose: Our aim was to describe the clinical and electrical features and the long-term evolution of childhood occipital epilepsy of Gastaut (COE-G) in a cohort of patients and to compare long-term prognosis between patients with and without other epileptic syndromes. Methods: This was a retrospective analysis of the long-term outcome of epilepsy in 129 patients with COE-G who were referred to 23 Italian epilepsy centres and one in Austria between 1991 and 2004. Patients were evaluated clinically and with electroencephalograms for 10.1-23.0 years. The following clinical characteristics were evaluated: gender, patient age at seizure onset, history of febrile seizures and migraine, family history of epilepsy, duration and seizure manifestations, circadian distribution and frequency of seizures, history of medications including the number of drugs, therapeutic response and final outcome. Results: Visual hallucinations were the first symptom in 62% and the only manifestation in 38.8% of patients. Patients were subdivided into two groups: group A with isolated COE-G; group B with other epileptic syndromes associated with COE-G. The most significant (P <0.05) difference concerned antiepileptic therapy: in group A, 45 children responded to monotherapy; in group B only 15 children responded to monotherapy. At the end of follow-up, the percentage of seizure-free patients was significantly higher in group A than in group B. Conclusions: Childhood occipital epilepsy of Gastaut has an overall favourable prognosis and a good response to antiepileptic therapy with resolution of seizures and of electroencephalogram abnormalities. The association of typical COE-G symptoms with other types of seizure could be related to a poor epilepsy outcome.

Original languageEnglish
Pages (from-to)241-246
Number of pages6
JournalEuropean Journal of Neurology
Volume23
Issue number2
DOIs
Publication statusPublished - Feb 1 2016

Fingerprint

Dissection
Epilepsy
Seizures
Anticonvulsants
Electroencephalography
Febrile Seizures
Austria
Hallucinations
Group Psychotherapy
Migraine Disorders
Age of Onset
Therapeutics
Pharmaceutical Preparations

Keywords

  • EEG
  • Antiepileptic therapy
  • Focal epilepsy
  • Generalized epilepsy
  • Idiopathic occipital epilepsy
  • Outcome

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Verrotti, A., Laino, D., Rinaldi, V. E., Suppiej, A., Giordano, L., Toldo, I., ... Spalice, A. (2016). Clinical dissection of childhood occipital epilepsy of Gastaut and prognostic implication. European Journal of Neurology, 23(2), 241-246. https://doi.org/10.1111/ene.12840

Clinical dissection of childhood occipital epilepsy of Gastaut and prognostic implication. / Verrotti, Alberto; Laino, Daniela; Rinaldi, Victoria Elisa; Suppiej, A.; Giordano, L.; Toldo, Irene; Margari, Lucia; Parisi, P.; Rizzo, R.; Matricardi, Sara; Cusmai, Raffaella; Grosso, Salvatore; Gaggero, R.; Zamponi, Nelia; Pavone, P.; Capovilla, Giuseppe; Rauchenzauner, M.; Cerminara, C.; Di Gennaro, Giancarlo; Esposito, Maria; Striano, Pasquale; Savasta, Salvatore; Coppola, Giangennaro; Siliquini, Sabrina; Operto, Francesca; Belcastro, Vincenzo; Ragona, Francesca; Marseglia, Gianluigi; Spalice, Alberto.

In: European Journal of Neurology, Vol. 23, No. 2, 01.02.2016, p. 241-246.

Research output: Contribution to journalArticle

Verrotti, A, Laino, D, Rinaldi, VE, Suppiej, A, Giordano, L, Toldo, I, Margari, L, Parisi, P, Rizzo, R, Matricardi, S, Cusmai, R, Grosso, S, Gaggero, R, Zamponi, N, Pavone, P, Capovilla, G, Rauchenzauner, M, Cerminara, C, Di Gennaro, G, Esposito, M, Striano, P, Savasta, S, Coppola, G, Siliquini, S, Operto, F, Belcastro, V, Ragona, F, Marseglia, G & Spalice, A 2016, 'Clinical dissection of childhood occipital epilepsy of Gastaut and prognostic implication', European Journal of Neurology, vol. 23, no. 2, pp. 241-246. https://doi.org/10.1111/ene.12840
Verrotti A, Laino D, Rinaldi VE, Suppiej A, Giordano L, Toldo I et al. Clinical dissection of childhood occipital epilepsy of Gastaut and prognostic implication. European Journal of Neurology. 2016 Feb 1;23(2):241-246. https://doi.org/10.1111/ene.12840
Verrotti, Alberto ; Laino, Daniela ; Rinaldi, Victoria Elisa ; Suppiej, A. ; Giordano, L. ; Toldo, Irene ; Margari, Lucia ; Parisi, P. ; Rizzo, R. ; Matricardi, Sara ; Cusmai, Raffaella ; Grosso, Salvatore ; Gaggero, R. ; Zamponi, Nelia ; Pavone, P. ; Capovilla, Giuseppe ; Rauchenzauner, M. ; Cerminara, C. ; Di Gennaro, Giancarlo ; Esposito, Maria ; Striano, Pasquale ; Savasta, Salvatore ; Coppola, Giangennaro ; Siliquini, Sabrina ; Operto, Francesca ; Belcastro, Vincenzo ; Ragona, Francesca ; Marseglia, Gianluigi ; Spalice, Alberto. / Clinical dissection of childhood occipital epilepsy of Gastaut and prognostic implication. In: European Journal of Neurology. 2016 ; Vol. 23, No. 2. pp. 241-246.
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AU - Verrotti, Alberto

AU - Laino, Daniela

AU - Rinaldi, Victoria Elisa

AU - Suppiej, A.

AU - Giordano, L.

AU - Toldo, Irene

AU - Margari, Lucia

AU - Parisi, P.

AU - Rizzo, R.

AU - Matricardi, Sara

AU - Cusmai, Raffaella

AU - Grosso, Salvatore

AU - Gaggero, R.

AU - Zamponi, Nelia

AU - Pavone, P.

AU - Capovilla, Giuseppe

AU - Rauchenzauner, M.

AU - Cerminara, C.

AU - Di Gennaro, Giancarlo

AU - Esposito, Maria

AU - Striano, Pasquale

AU - Savasta, Salvatore

AU - Coppola, Giangennaro

AU - Siliquini, Sabrina

AU - Operto, Francesca

AU - Belcastro, Vincenzo

AU - Ragona, Francesca

AU - Marseglia, Gianluigi

AU - Spalice, Alberto

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KW - EEG

KW - Antiepileptic therapy

KW - Focal epilepsy

KW - Generalized epilepsy

KW - Idiopathic occipital epilepsy

KW - Outcome

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