Clinical effectiveness of bare-metal stenting compared with balloon angioplasty in total coronary occlusions: Insights from a systematic overview of randomized trials in light of the drug-eluting stent era

Pierfrancesco Agostoni, Marco Valgimigli, Giuseppe G L Biondi-Zoccai, Antonio Abbate, Hector M. Garcia Garcia, Maurizio Anselmi, Marco Turri, Eugene P. McFadden, Corrado Vassanelli, Patrick W. Serruys, Antonio Colombo

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Abstract

Background: We sought to compare, using meta-analytic techniques, bare-metal stent versus balloon angioplasty in the percutaneous treatment of total coronary occlusions by means of a quantitative systematic review and to indicate new avenues for future treatments. Methods: MEDLINE and CENTRAL were searched. Inclusion criteria were random allocation, prospective comparison, and intention to treat. Random-effect odds ratios (ORs) with 95% confidence intervals (CIs) for death, myocardial infarction (MI), repeated revascularization, major adverse cardiac events (MACE), and angiographic restenosis and reocclusion were computed. Results: Nine trials (1409 patients) were included. Death rate was not different in the 2 groups, 0.4% after stenting versus 0.7% after balloon angioplasty (OR 0.72, 95% CI 0.21-2.50). MI rate was significantly increased after stenting (6.7% vs 3.4%, OR 2.06, 95% CI 1.22-3.46), mainly because of a higher rate of periprocedural non-Q-wave MI. By contrast, the risk of repeated revascularization was significantly reduced by stenting (17% vs 32%, OR 0.41, 95% CI 0.31-0.53). This yielded to an overall reduction in the rate of MACE after stenting (23.2% vs 35.4%, OR 0.49, 95% CI 0.36-0.68). Angiographic restenosis and reocclusion were also decreased by stent (41.1% vs 60.9%, OR 0.36, 95% CI 0.23-0.57; 6.8% vs 16%, OR 0.36, 95% CI 0.22-0.59, respectively). Conclusions: In total coronary occlusions, stenting yields an important benefit over balloon angioplasty in reduction of MACE, repeated revascularizations, and angiographic restenosis and reocclusion. However, these events remain frequent. Moreover, the finding of an increased rate of periprocedural minor myocardial damage after stenting casts caution. New strategies aimed to reduce the need of repeated revascularizations and periprocedural MIs should be further investigated.

Original languageEnglish
Pages (from-to)682-689
Number of pages8
JournalAmerican Heart Journal
Volume151
Issue number3
DOIs
Publication statusPublished - Mar 2006

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ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Agostoni, P., Valgimigli, M., Biondi-Zoccai, G. G. L., Abbate, A., Garcia Garcia, H. M., Anselmi, M., Turri, M., McFadden, E. P., Vassanelli, C., Serruys, P. W., & Colombo, A. (2006). Clinical effectiveness of bare-metal stenting compared with balloon angioplasty in total coronary occlusions: Insights from a systematic overview of randomized trials in light of the drug-eluting stent era. American Heart Journal, 151(3), 682-689. https://doi.org/10.1016/j.ahj.2005.05.001