Abstract
Forty patients with functional dyspepsia were treated under double-blind conditions with levosulpiride (75 mg/day) or with domperidone (60 mg/day) for four weeks. Levosulpiride, but not domperidone, significantly reduced nausea and vomiting; both drugs were efficacious in significantly reducing the other symptoms. Levosulpiride, but not domperidone, significantly shortened gastric emptying time (determined by the ultrasonographic method). Neither drug modified the presence of Helicobacter pylori in gastric mucosa. Our study confirmed that levosulpiride represents a good choice in patients with functional dyspepsia, especially when delayed gastric emptying, nausea, and vomiting are present.
| Original language | English |
|---|---|
| Pages (from-to) | 715-722 |
| Number of pages | 8 |
| Journal | Current Therapeutic Research |
| Volume | 51 |
| Issue number | 5 |
| Publication status | Published - 1992 |
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ASJC Scopus subject areas
- Medicine(all)
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Clinical efficacy and safety of levosulpiride and domperidone in the management of chronic functional dyspepsia : A double-blind, randomized clinical trial. / Gatto, G.; Ricca, T.; Randazzo, M. A.; Di Piazza, S.; Maringhini, A.; Trapani, G.; Baccelliere, P.; Montalbano, L.; Barresi, L. S.
In: Current Therapeutic Research, Vol. 51, No. 5, 1992, p. 715-722.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clinical efficacy and safety of levosulpiride and domperidone in the management of chronic functional dyspepsia
T2 - A double-blind, randomized clinical trial
AU - Gatto, G.
AU - Ricca, T.
AU - Randazzo, M. A.
AU - Di Piazza, S.
AU - Maringhini, A.
AU - Trapani, G.
AU - Baccelliere, P.
AU - Montalbano, L.
AU - Barresi, L. S.
PY - 1992
Y1 - 1992
N2 - Forty patients with functional dyspepsia were treated under double-blind conditions with levosulpiride (75 mg/day) or with domperidone (60 mg/day) for four weeks. Levosulpiride, but not domperidone, significantly reduced nausea and vomiting; both drugs were efficacious in significantly reducing the other symptoms. Levosulpiride, but not domperidone, significantly shortened gastric emptying time (determined by the ultrasonographic method). Neither drug modified the presence of Helicobacter pylori in gastric mucosa. Our study confirmed that levosulpiride represents a good choice in patients with functional dyspepsia, especially when delayed gastric emptying, nausea, and vomiting are present.
AB - Forty patients with functional dyspepsia were treated under double-blind conditions with levosulpiride (75 mg/day) or with domperidone (60 mg/day) for four weeks. Levosulpiride, but not domperidone, significantly reduced nausea and vomiting; both drugs were efficacious in significantly reducing the other symptoms. Levosulpiride, but not domperidone, significantly shortened gastric emptying time (determined by the ultrasonographic method). Neither drug modified the presence of Helicobacter pylori in gastric mucosa. Our study confirmed that levosulpiride represents a good choice in patients with functional dyspepsia, especially when delayed gastric emptying, nausea, and vomiting are present.
UR - http://www.scopus.com/inward/record.url?scp=0026521166&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026521166&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0026521166
VL - 51
SP - 715
EP - 722
JO - Current Therapeutic Research - Clinical and Experimental
JF - Current Therapeutic Research - Clinical and Experimental
SN - 0011-393X
IS - 5
ER -