Clinical efficacy and safety of levosulpiride and domperidone in the management of chronic functional dyspepsia: A double-blind, randomized clinical trial

G. Gatto; T. Ricca; M. A. Randazzo; S. Di Piazza; A. Maringhini; G. Trapani; P. Baccelliere; L. Montalbano; L. S. Barresi

Clinical efficacy and safety of levosulpiride and domperidone in the management of chronic functional dyspepsia: A double-blind, randomized clinical trial

G. Gatto, T. Ricca, M. A. Randazzo, S. Di Piazza, A. Maringhini, G. Trapani, P. Baccelliere, L. Montalbano, L. S. Barresi

ISMETT

Research output: Contribution to journal › Article › peer-review

Abstract

Forty patients with functional dyspepsia were treated under double-blind conditions with levosulpiride (75 mg/day) or with domperidone (60 mg/day) for four weeks. Levosulpiride, but not domperidone, significantly reduced nausea and vomiting; both drugs were efficacious in significantly reducing the other symptoms. Levosulpiride, but not domperidone, significantly shortened gastric emptying time (determined by the ultrasonographic method). Neither drug modified the presence of Helicobacter pylori in gastric mucosa. Our study confirmed that levosulpiride represents a good choice in patients with functional dyspepsia, especially when delayed gastric emptying, nausea, and vomiting are present.

Original language	English
Pages (from-to)	715-722
Number of pages	8
Journal	Current Therapeutic Research
Volume	51
Issue number	5
Publication status	Published - 1992

ASJC Scopus subject areas

Medicine(all)

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Clinical efficacy and safety of levosulpiride and domperidone in the management of chronic functional dyspepsia : A double-blind, randomized clinical trial. / Gatto, G.; Ricca, T.; Randazzo, M. A.; Di Piazza, S.; Maringhini, A.; Trapani, G.; Baccelliere, P.; Montalbano, L.; Barresi, L. S.

In: Current Therapeutic Research, Vol. 51, No. 5, 1992, p. 715-722.

Research output: Contribution to journal › Article › peer-review

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abstract = "Forty patients with functional dyspepsia were treated under double-blind conditions with levosulpiride (75 mg/day) or with domperidone (60 mg/day) for four weeks. Levosulpiride, but not domperidone, significantly reduced nausea and vomiting; both drugs were efficacious in significantly reducing the other symptoms. Levosulpiride, but not domperidone, significantly shortened gastric emptying time (determined by the ultrasonographic method). Neither drug modified the presence of Helicobacter pylori in gastric mucosa. Our study confirmed that levosulpiride represents a good choice in patients with functional dyspepsia, especially when delayed gastric emptying, nausea, and vomiting are present.",

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T2 - A double-blind, randomized clinical trial

AU - Gatto, G.

AU - Ricca, T.

AU - Randazzo, M. A.

AU - Di Piazza, S.

AU - Maringhini, A.

AU - Trapani, G.

AU - Baccelliere, P.

AU - Montalbano, L.

AU - Barresi, L. S.

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AB - Forty patients with functional dyspepsia were treated under double-blind conditions with levosulpiride (75 mg/day) or with domperidone (60 mg/day) for four weeks. Levosulpiride, but not domperidone, significantly reduced nausea and vomiting; both drugs were efficacious in significantly reducing the other symptoms. Levosulpiride, but not domperidone, significantly shortened gastric emptying time (determined by the ultrasonographic method). Neither drug modified the presence of Helicobacter pylori in gastric mucosa. Our study confirmed that levosulpiride represents a good choice in patients with functional dyspepsia, especially when delayed gastric emptying, nausea, and vomiting are present.

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Clinical efficacy and safety of levosulpiride and domperidone in the management of chronic functional dyspepsia: A double-blind, randomized clinical trial

Abstract

ASJC Scopus subject areas

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