Clinical efficacy and safety of levosulpiride and domperidone in the management of chronic functional dyspepsia: A double-blind, randomized clinical trial

G. Gatto, T. Ricca, M. A. Randazzo, S. Di Piazza, A. Maringhini, G. Trapani, P. Baccelliere, L. Montalbano, L. S. Barresi

Research output: Contribution to journalArticlepeer-review

Abstract

Forty patients with functional dyspepsia were treated under double-blind conditions with levosulpiride (75 mg/day) or with domperidone (60 mg/day) for four weeks. Levosulpiride, but not domperidone, significantly reduced nausea and vomiting; both drugs were efficacious in significantly reducing the other symptoms. Levosulpiride, but not domperidone, significantly shortened gastric emptying time (determined by the ultrasonographic method). Neither drug modified the presence of Helicobacter pylori in gastric mucosa. Our study confirmed that levosulpiride represents a good choice in patients with functional dyspepsia, especially when delayed gastric emptying, nausea, and vomiting are present.

Original languageEnglish
Pages (from-to)715-722
Number of pages8
JournalCurrent Therapeutic Research
Volume51
Issue number5
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Clinical efficacy and safety of levosulpiride and domperidone in the management of chronic functional dyspepsia: A double-blind, randomized clinical trial'. Together they form a unique fingerprint.

Cite this