Clinical efficacy of ribociclib as a first-line therapy for HR-positive, advanced breast cancer

Bruno Achutti Duso, Dario Trapani, Giulia Viale, Carmen Criscitiello, Paolo D’Amico, Carmen Belli, Luca Mazzarella, Marzia Locatelli, Ida Minchella, Giuseppe Curigliano

Research output: Contribution to journalArticle

Abstract

Introduction: Breast cancer (BC) remains the most frequently diagnosed cancer and the most common cause of cancer death among women of all races worldwide. Over 80% of BC cases are hormone receptor (HR)-positive, comprised of luminal A and luminal B per molecular subtypes, imposing an urgent need to fully understand the mechanisms behind progression. Ribociclib is a selective cycline-dependent kinase 4 and 6 inhibitor. A phase 1 and a phase 3 trial have established a definitive role of ribociclib as frontline in the treatment of endocrine-sensitive advanced BC. Areas covered: Herein, the authors provide an overview of the data on ribociclib covering all aspects of the drug from its pharmacokinetics to efficacy and safety. The authors also provide their perspectives for the future. Expert opinion: Ribociclib is offering an opportunity to explore a new compound at the crossroads of different molecular activity and cell targets, which focus on endocrine-resistance reversal in multiple settings including early BC. Moreover, its activity against different subtypes of BC is being studied as is its immune-modulating effect. One cautionary note is that, in a market of concomitant similar competitors, a financial discussion will be mandatory.

Original languageEnglish
Pages (from-to)299-305
Number of pages7
JournalExpert Opinion on Pharmacotherapy
Volume19
Issue number3
DOIs
Publication statusPublished - Feb 11 2018

Keywords

  • breast cancer
  • CDK4/6
  • endocrine-resistance
  • immune checkpoint
  • immunotherapy
  • LEE011
  • Ribociclib

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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