Clinical, epidemiological and virological features of acute hepatitis B in Italy

Ornella Zuccaro, Luisa Romanò, Alfonso Mele, Andrea Mariano, Massimo Clementi, Maria Elena Tosti, Gloria Taliani, Claudio Galli, Alessandro Remo Zanetti, Enea Spada

Research output: Contribution to journalArticlepeer-review


Purpose: To evaluate the association of hepatitis B virus (HBV) genotypes, basal core promoter (BCP)/precore (PC) and S gene mutations with the clinical-epidemiological characteristics of acute hepatitis B (AHB) in Italy. Methods: During July 2005–January 2007, 103 symptomatic AHB patients were enrolled and prospectively followed up at 15 national hospitals. HBV genotypes, BCP/PC and S gene variants were determined by nested-PCR and direct sequence analysis. Results: Genotype D, A and F were detected in 49, 45 and 6 % of patients, respectively. BCP, PC, and BCP plus PC variants were found in 3.1, 11.3 and 7.2 % of patients, respectively. At enrollment, 68.3 % of patients were hepatitis B e antigen (HBeAg)-positive and 31.7 % HBeAg-negative. BCP/PC mutations were more common in HBeAg-negative than in HBeAg-positive patients (p 

Original languageEnglish
Pages (from-to)431-441
Number of pages11
Issue number4
Publication statusPublished - Feb 20 2015


  • Acute infection
  • Epidemiology
  • Genotypes
  • Hepatitis B
  • Mutations
  • Risk factors

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases


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