TY - JOUR
T1 - Clinical, epidemiological and virological features of acute hepatitis B in Italy
AU - Zuccaro, Ornella
AU - Romanò, Luisa
AU - Mele, Alfonso
AU - Mariano, Andrea
AU - Clementi, Massimo
AU - Tosti, Maria Elena
AU - Taliani, Gloria
AU - Galli, Claudio
AU - Zanetti, Alessandro Remo
AU - Spada, Enea
PY - 2015/2/20
Y1 - 2015/2/20
N2 - Purpose: To evaluate the association of hepatitis B virus (HBV) genotypes, basal core promoter (BCP)/precore (PC) and S gene mutations with the clinical-epidemiological characteristics of acute hepatitis B (AHB) in Italy. Methods: During July 2005–January 2007, 103 symptomatic AHB patients were enrolled and prospectively followed up at 15 national hospitals. HBV genotypes, BCP/PC and S gene variants were determined by nested-PCR and direct sequence analysis. Results: Genotype D, A and F were detected in 49, 45 and 6 % of patients, respectively. BCP, PC, and BCP plus PC variants were found in 3.1, 11.3 and 7.2 % of patients, respectively. At enrollment, 68.3 % of patients were hepatitis B e antigen (HBeAg)-positive and 31.7 % HBeAg-negative. BCP/PC mutations were more common in HBeAg-negative than in HBeAg-positive patients (p
AB - Purpose: To evaluate the association of hepatitis B virus (HBV) genotypes, basal core promoter (BCP)/precore (PC) and S gene mutations with the clinical-epidemiological characteristics of acute hepatitis B (AHB) in Italy. Methods: During July 2005–January 2007, 103 symptomatic AHB patients were enrolled and prospectively followed up at 15 national hospitals. HBV genotypes, BCP/PC and S gene variants were determined by nested-PCR and direct sequence analysis. Results: Genotype D, A and F were detected in 49, 45 and 6 % of patients, respectively. BCP, PC, and BCP plus PC variants were found in 3.1, 11.3 and 7.2 % of patients, respectively. At enrollment, 68.3 % of patients were hepatitis B e antigen (HBeAg)-positive and 31.7 % HBeAg-negative. BCP/PC mutations were more common in HBeAg-negative than in HBeAg-positive patients (p
KW - Acute infection
KW - Epidemiology
KW - Genotypes
KW - Hepatitis B
KW - Mutations
KW - Risk factors
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U2 - 10.1007/s15010-015-0747-0
DO - 10.1007/s15010-015-0747-0
M3 - Article
C2 - 25697541
AN - SCOPUS:84938416743
VL - 43
SP - 431
EP - 441
JO - Infection
JF - Infection
SN - 0300-8126
IS - 4
ER -