Clinical, epidemiological and virological features of acute hepatitis B in Italy

Ornella Zuccaro; Luisa Romanò; Alfonso Mele; Andrea Mariano; Massimo Clementi; Maria Elena Tosti; Gloria Taliani; Claudio Galli; Alessandro Remo Zanetti; Enea Spada

doi:10.1007/s15010-015-0747-0

Clinical, epidemiological and virological features of acute hepatitis B in Italy

Ornella Zuccaro, Luisa Romanò, Alfonso Mele, Andrea Mariano, Massimo Clementi, Maria Elena Tosti, Gloria Taliani, Claudio Galli, Alessandro Remo Zanetti, Enea Spada

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: To evaluate the association of hepatitis B virus (HBV) genotypes, basal core promoter (BCP)/precore (PC) and S gene mutations with the clinical-epidemiological characteristics of acute hepatitis B (AHB) in Italy. Methods: During July 2005–January 2007, 103 symptomatic AHB patients were enrolled and prospectively followed up at 15 national hospitals. HBV genotypes, BCP/PC and S gene variants were determined by nested-PCR and direct sequence analysis. Results: Genotype D, A and F were detected in 49, 45 and 6 % of patients, respectively. BCP, PC, and BCP plus PC variants were found in 3.1, 11.3 and 7.2 % of patients, respectively. At enrollment, 68.3 % of patients were hepatitis B e antigen (HBeAg)-positive and 31.7 % HBeAg-negative. BCP/PC mutations were more common in HBeAg-negative than in HBeAg-positive patients (p

Original language	English
Pages (from-to)	431-441
Number of pages	11
Journal	Infection
Volume	43
Issue number	4
DOIs	https://doi.org/10.1007/s15010-015-0747-0
Publication status	Published - Feb 20 2015

Keywords

Acute infection
Epidemiology
Genotypes
Hepatitis B
Mutations
Risk factors

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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Clinical, epidemiological and virological features of acute hepatitis B in Italy. / Zuccaro, Ornella; Romanò, Luisa; Mele, Alfonso; Mariano, Andrea ; Clementi, Massimo; Tosti, Maria Elena; Taliani, Gloria; Galli, Claudio; Zanetti, Alessandro Remo; Spada, Enea.

In: Infection, Vol. 43, No. 4, 20.02.2015, p. 431-441.

Research output: Contribution to journal › Article › peer-review

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AU - Mele, Alfonso

AU - Mariano, Andrea

AU - Clementi, Massimo

AU - Tosti, Maria Elena

AU - Taliani, Gloria

AU - Galli, Claudio

AU - Zanetti, Alessandro Remo

AU - Spada, Enea

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