Clinical evaluation of 4′-epi-doxorubicin in advanced solid tumors

Gioacchino Robustelli Della Cuna, Lorenzo Pavesi, Piero Preti, Fabrizio Ganzina

Research output: Contribution to journalArticlepeer-review

Abstract

A Phase II clinical evaluation of 4′-epi-doxorubicin has been carried out in 100 patients with various types of solid tumors. Hematopoietic toxicity was dose-limiting but reversible and of mild to moderate degree. Other acute toxic manifestations such as vomiting and alopecia were qualitatively similar to those usually reported for doxorubicin, but lower in frequency and less severe. A number of responding patients received cumulative doses of 4′-epi-doxorubicin in excess of 500 mg/m2. One patient manifested reversible clinical congestive heart failure at cumulative dose of 1,080 mg/m2. Therapeutic activity has been observed in breast carcinoma, in rectal carcinoma and in melanoma. In chemoresistant tumors as rectal cancer and melanoma 4′-epi-doxorubicin deserves further study.

Original languageEnglish
Pages (from-to)349-353
Number of pages5
JournalInvestigational New Drugs
Volume1
Issue number4
DOIs
Publication statusPublished - Dec 1983

Keywords

  • 4′-epi-doxorubicin
  • clinical toxicity
  • doxorubicin
  • therapeutic efficacy

ASJC Scopus subject areas

  • Pharmacology
  • Molecular Medicine

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