Clinical evaluation of a fully automated chromogenic method for prothrombin time compared with a conventional coagulation method

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Abstract

The clinical usefulness of a chromogenic method for prothrombin time (PT) determination has been assessed in a wide range of clinical conditions, and it is compared with the conventional clotting method for PT. The new method appears to be as sensitive as the clotting PT to deficiencies of clotting factors of the extrinsic and common pathway, except for fibrinogen. Patients with proven liver disease were correctly diagnosed with a prevalence of abnormal results comparable to that by the clotting PT. Results by the two methods correlated highly (r = 0.96) for normal and congenitally deficient plasmas as well as for plasmas from patients on oral anticoagulant treatment (r = 0.95). High reproducibility (between-assay CV

Original languageEnglish
Pages (from-to)1392-1395
Number of pages4
JournalClinical Chemistry
Volume30
Issue number8
Publication statusPublished - 1984

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Chromogenics
Prothrombin Time
Prothrombin
Coagulation
Plasmas
Blood Coagulation Factors
Liver
Anticoagulants
Fibrinogen
Liver Diseases
Assays

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

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abstract = "The clinical usefulness of a chromogenic method for prothrombin time (PT) determination has been assessed in a wide range of clinical conditions, and it is compared with the conventional clotting method for PT. The new method appears to be as sensitive as the clotting PT to deficiencies of clotting factors of the extrinsic and common pathway, except for fibrinogen. Patients with proven liver disease were correctly diagnosed with a prevalence of abnormal results comparable to that by the clotting PT. Results by the two methods correlated highly (r = 0.96) for normal and congenitally deficient plasmas as well as for plasmas from patients on oral anticoagulant treatment (r = 0.95). High reproducibility (between-assay CV",
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