Clinical evaluation of a hyaluronan-based gel following microsurgical reconstruction of peripheral nerves of the hand

Andrea Atzei, Maurizio Calcagni, Bruno Breda, Giampaolo Fasolo, Giorgio Pajardi, Landino Cugola

Research output: Contribution to journalArticlepeer-review

Abstract

A controlled clinical trial was performed to investigate the safety and efficacy of the hyaluronate-based gel polymer Hyaloglide® after microsurgical reconstruction of peripheral nerves of the hand. Thirty patients were randomized to receive either no postsurgical treatment (n = 16) or Hyaloglide® (n = 14) and were clinically evaluated at various intervals for 1 year. The application of Hyaloglide® posed no safety concerns. Efficacy was assessed by the recovery of sensitivity, measurement of pain, and progression of Tinel's sign. The Hyaloglide®-treated group showed better improvement in recovery from pain, approaching statistical significance during the first 3 months postsurgery. Likewise, recovery of sensitivity was also higher in the Hyaloglide®-treated group throughout the entire follow-up period, and the distance of Tinel's sign was longer in the Hyaloglide®- treated group (P <0.05 at day 30). The application of Hyaloglide® may improve recovery of sensitivity and decrease pain following microsurgical repair of the peripheral nerves of the hand.

Original languageEnglish
Pages (from-to)2-7
Number of pages6
JournalMicrosurgery
Volume27
Issue number1
DOIs
Publication statusPublished - 2007

ASJC Scopus subject areas

  • Surgery

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