Valutazione clinica dell'atracurium besilato nei pazienti a rischio: il grande ustionato.

Translated title of the contribution: Clinical evaluation of atracurium besylate in patients at risk: major burns

C. D'Eramo, N. Stocchetti, A. Vezzani

Research output: Contribution to journalArticle


Atracurium besylate 0.5 mg/kg-1, an intermediate-duration non-depolarizing neuromuscular relaxant, was administered slowly (over 75 sec) in anesthesia induction of 61 patients with major thermal injury undergoing surgical excision and immediate skin-grafting procedures. Patients' mean +/- SD age was 40 +/- 9, body weight 64 +/- 2, burn size ranging from 20% to 90% of body surface area (BSA), postburn day of surgery 5th and more. Induction of anesthesia was carried out with sodium thiopental 2-5 mg/kg-1 plus fentanyl 2.8 micrograms/kg-1 e.v. and after few minutes atracurium 0.5 mg/kg-1 e.v. Anesthesia was maintained with N2O/O2 (70%/30%), isoflurane and small amounts of fentanyl. The mean arterial pressure and heart rate were recorded at I, II, III, IV, V min post atracurium administration. The endotracheal intubation conditions were assessed by a "IOT score". Results are expressed as mean value +/- standard deviation. The significance of the difference in mean values was analysed by t-test. Little haemodynamic changes occurred; intubating conditions showed a relative hyposensitivity of burn patients to atracurium, more severely burned patients (greater than 50-60%) exhibiting greater resistance.

Translated title of the contributionClinical evaluation of atracurium besylate in patients at risk: major burns
Original languageItalian
Pages (from-to)121-125
Number of pages5
JournalMinerva Anestesiologica
Issue number4
Publication statusPublished - Apr 1990

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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