Clinical evaluation of probucol in hypercholesterolemia: Individual lipoprotein responses and inhibitory effect on carotid atherosclerosis progression

Damiano Baldassarre, Guido Franceschini, Giulia Peruzzotti, Bruno Brusoni, Cesare R. Sirtori

Research output: Contribution to journalArticlepeer-review

Abstract

Probucol treatment has been evaluated in 140 patients with hypercholesterolemia attending a single Lipid Clinic, in an attempt to identify the relations between lipid/lipoprotein responses and patient characteristics. Probucol was administered as a single drug at the standard dose (0.5 g tables b.i.d.) for at least 6 months. One-hundred (71%) patients displayed a reduction of low-density lipoprotein cholesterol (LDL-C), which was significantly correlated with the baseline LDL-C level (r = 0.64; p <0.0001). Most of the patients (90%) also responded with a reduction of high- density lipoprotein cholesterol (HDL-C); the HDL-C reduction was also directly related to baseline HDL cholesterolemia (r = 0.67, p <0.0001). A highly significant correlation was found between the individual LDL-C and HDL-C responses. Eleven patients who continued with probucol treatment had a B-mode ultrasonographic investigation performed at baseline and after 24 months. No changes in carotid mean and maximal intimal-medial thickness were recorded, in contrast to an increase (i.e., indicative of atherosclerosis progression) in matched patients with hypercholesterolemia receiving other lipid-lowering regimens. Our report underlines that probucol can still provide a valuable option for the treatment for hypercholesterolemia, being particularly effective in patients with a combined increase of LDL-C and HDL- C levels.

Original languageEnglish
Pages (from-to)784-789
Number of pages6
JournalJournal of Cardiovascular Pharmacology
Volume30
Issue number6
DOIs
Publication statusPublished - Dec 1997

Keywords

  • Carotid intimal-medial thickness
  • HDL cholesterol
  • Hypercholesterolemia
  • LDL cholesterol
  • Probucol

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology

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