TY - JOUR
T1 - Clinical experience with fondaparinux in antiaggregate patients undergoing total hip and knee arthroplasty
AU - Grappiolo, Guido
AU - Scardino, Marco
AU - Mazziotta, Giuseppe
AU - Quaini, Stefano
AU - Lodigiani, Corrado
AU - Ferrari, Matteo Carlo
PY - 2013
Y1 - 2013
N2 - Patients undergoing total hip arthroplasty or total knee arthroplasty have a high risk for post-operative venous thromboembolism. The current study addressed the use of fondaparinux post-operatively in 556 patients with antiplatelet therapy in order to prevent deep vein thrombosis as well as demonstrate efficacy in preventing arterial thrombotic events. Results provided evidence for a safe and effective prophylaxis strategy, involving the change from low molecular weight heparin pre-operatively to fondaparinux postoperatively. Also, fondaparinux proved effective as a unique post-operative therapy in the prevention of venous thromboembolism with no adverse effects, such as major bleeding or arterial thrombosis in patients with pre-operative antiplatelet therapy.
AB - Patients undergoing total hip arthroplasty or total knee arthroplasty have a high risk for post-operative venous thromboembolism. The current study addressed the use of fondaparinux post-operatively in 556 patients with antiplatelet therapy in order to prevent deep vein thrombosis as well as demonstrate efficacy in preventing arterial thrombotic events. Results provided evidence for a safe and effective prophylaxis strategy, involving the change from low molecular weight heparin pre-operatively to fondaparinux postoperatively. Also, fondaparinux proved effective as a unique post-operative therapy in the prevention of venous thromboembolism with no adverse effects, such as major bleeding or arterial thrombosis in patients with pre-operative antiplatelet therapy.
KW - Antiplatelet therapy
KW - Fondaparinux
KW - Postoperative venous thromboembolism prophylaxis
KW - Total hip arthroplasty
KW - Total knee arthroplasty
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U2 - 10.4081/itjm.2013.179
DO - 10.4081/itjm.2013.179
M3 - Article
AN - SCOPUS:84890170670
VL - 7
SP - 179
EP - 182
JO - Italian Journal of Medicine
JF - Italian Journal of Medicine
SN - 1877-9344
IS - 3
ER -