Clinical experience with fondaparinux in antiaggregate patients undergoing total hip and knee arthroplasty

Guido Grappiolo, Marco Scardino, Giuseppe Mazziotta, Stefano Quaini, Corrado Lodigiani, Matteo Carlo Ferrari

Research output: Contribution to journalArticle


Patients undergoing total hip arthroplasty or total knee arthroplasty have a high risk for post-operative venous thromboembolism. The current study addressed the use of fondaparinux post-operatively in 556 patients with antiplatelet therapy in order to prevent deep vein thrombosis as well as demonstrate efficacy in preventing arterial thrombotic events. Results provided evidence for a safe and effective prophylaxis strategy, involving the change from low molecular weight heparin pre-operatively to fondaparinux postoperatively. Also, fondaparinux proved effective as a unique post-operative therapy in the prevention of venous thromboembolism with no adverse effects, such as major bleeding or arterial thrombosis in patients with pre-operative antiplatelet therapy.

Original languageEnglish
Pages (from-to)179-182
Number of pages4
JournalItalian Journal of Medicine
Issue number3
Publication statusPublished - 2013



  • Antiplatelet therapy
  • Fondaparinux
  • Postoperative venous thromboembolism prophylaxis
  • Total hip arthroplasty
  • Total knee arthroplasty

ASJC Scopus subject areas

  • Medicine(all)

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