The secondary complications of diabetes mellitus are the main cause of morbidity and mortality associated with the disease, and seem to be related to inadequate metabolic control achieved by traditional treatments. Pancreatic transplantation is a promising approach to normoglycaemia through a self-regulated source of insulin. There is experimental evidence that pancreas transplantation may prevent degenerative complications of diabetes and reverse microangiopathic renal lesions. Nevertheless, technical aspects of pancreatic transplantation remain to be solved on disposal of the exocrine secretions. Several methods have been proposed: pancreatic duct ligation, intestinal diversion, injection of the pancreatic duct with polymers, and urinary diversion. Intracanalicolar Neoprene (Dupont, Wilmington, DE) injection, which produces atrophy of the exocrine portion of the pancreas with preservation of the beta cells, is in our experience, a safe technique. Nevertheless many authors have reported fibrosis extending to the endocrine portion of the pancreatic graft, and this could cause loss of a pancreatic graft in the long term. The aim of this study was to investigate the long-term endocrine metabolic function and degenerative complications of patients allotransplanted with Neoprene-injected pancreas.
|Number of pages||2|
|Publication status||Published - 1986|
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