Clinical experience with ORTHOCLONE OKT3 in renal transplantation

C. Ponticelli, E. Rivolta, A. Tarantino

Research output: Contribution to journalArticle


ORTHOCLONE OKT3 is an IgG2a murine monoclonal antibody obtained by the hybridoma technique, which is directed against a 20-kD (kilodalton) glycoprotein on the membrane of mature T cells. This glycoprotein is an integral component of the antigen-recognition structure of the T cell. The interaction of ORTHOCLONE OKT3 causes a rapid and complete removal of the glycoprotein from the T-cell surface. Our exerience with ORTHOCLONE OKT3 for the reversal of acute renal rejection has included patients who were experiencing first rejection episodes as well as patients with severe rejection who were unresponsive to previously administered antirejection therapy.

Original languageEnglish
Pages (from-to)942-948
Number of pages7
JournalTransplantation Proceedings
Issue number4
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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    Ponticelli, C., Rivolta, E., & Tarantino, A. (1986). Clinical experience with ORTHOCLONE OKT3 in renal transplantation. Transplantation Proceedings, 18(4), 942-948.