TY - JOUR
T1 - Clinical expression of insulin resistance in hepatitis C and B virus-related chronic hepatitis
T2 - Differences and similarities
AU - Persico, Marcello
AU - Masarone, Mario
AU - La Mura, Vincenzo
AU - Persico, Eliana
AU - Moschella, Francesco
AU - Svelto, Monica
AU - Bruno, Savino
AU - Torella, Roberto
PY - 2009/1/28
Y1 - 2009/1/28
N2 - Aim: To investigate the prevalence of the clinical parameters of insulin resistance and diabetes in patients affected by chronic hepatitis C (CHC) or chronic hepatitis B (CHB). Methods: We retrospectively evaluated 852 consecutive patients (726 CHC and 126 CHB) who had undergone liver biopsy. We recorded age, sex, ALT, type 2 diabetes and/or metabolic syndrome (MS), body mass index (BMI), and apparent disease duration (ADD). Results: Age, ADD, BMI, prevalence of MS and diabetes in patients with mild/moderate liver fibrosis were significantly higher in CHC. However, the degree of steatosis and liver fibrosis evaluated in liver biopsies did not differ between CHC and CHB patients. At multivariate analysis, age, sex, BMI, ALT and diabetes were independent risk factors for liver fibrosis in CHC, whereas only age was related to liver fibrosis in CHB. We also evaluated the association between significant steatosis (> 30%) and age, sex, BMI, diabetes, MS and liver fibrosis. Diabetes, BMI and liver fibrosis were associated with steatosis > 30% in CHC, whereas only age and BMI were related to steatosis in CHB. Conclusion: These data may indicate that hepatitis C virus infection is a risk factor for insulin resistance.
AB - Aim: To investigate the prevalence of the clinical parameters of insulin resistance and diabetes in patients affected by chronic hepatitis C (CHC) or chronic hepatitis B (CHB). Methods: We retrospectively evaluated 852 consecutive patients (726 CHC and 126 CHB) who had undergone liver biopsy. We recorded age, sex, ALT, type 2 diabetes and/or metabolic syndrome (MS), body mass index (BMI), and apparent disease duration (ADD). Results: Age, ADD, BMI, prevalence of MS and diabetes in patients with mild/moderate liver fibrosis were significantly higher in CHC. However, the degree of steatosis and liver fibrosis evaluated in liver biopsies did not differ between CHC and CHB patients. At multivariate analysis, age, sex, BMI, ALT and diabetes were independent risk factors for liver fibrosis in CHC, whereas only age was related to liver fibrosis in CHB. We also evaluated the association between significant steatosis (> 30%) and age, sex, BMI, diabetes, MS and liver fibrosis. Diabetes, BMI and liver fibrosis were associated with steatosis > 30% in CHC, whereas only age and BMI were related to steatosis in CHB. Conclusion: These data may indicate that hepatitis C virus infection is a risk factor for insulin resistance.
KW - Diabetes
KW - Hepatitis B virus
KW - Hepatitis C virus
KW - Insulin resistance
KW - Metabolic syndrome
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U2 - 10.3748/wjg.15.462
DO - 10.3748/wjg.15.462
M3 - Article
C2 - 19152451
AN - SCOPUS:59249100878
VL - 15
SP - 462
EP - 466
JO - World Journal of Gastroenterology
JF - World Journal of Gastroenterology
SN - 1007-9327
IS - 4
ER -