Clinical expression of insulin resistance in hepatitis C and B virus-related chronic hepatitis: Differences and similarities

Marcello Persico, Mario Masarone, Vincenzo La Mura, Eliana Persico, Francesco Moschella, Monica Svelto, Savino Bruno, Roberto Torella

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: To investigate the prevalence of the clinical parameters of insulin resistance and diabetes in patients affected by chronic hepatitis C (CHC) or chronic hepatitis B (CHB). Methods: We retrospectively evaluated 852 consecutive patients (726 CHC and 126 CHB) who had undergone liver biopsy. We recorded age, sex, ALT, type 2 diabetes and/or metabolic syndrome (MS), body mass index (BMI), and apparent disease duration (ADD). Results: Age, ADD, BMI, prevalence of MS and diabetes in patients with mild/moderate liver fibrosis were significantly higher in CHC. However, the degree of steatosis and liver fibrosis evaluated in liver biopsies did not differ between CHC and CHB patients. At multivariate analysis, age, sex, BMI, ALT and diabetes were independent risk factors for liver fibrosis in CHC, whereas only age was related to liver fibrosis in CHB. We also evaluated the association between significant steatosis (> 30%) and age, sex, BMI, diabetes, MS and liver fibrosis. Diabetes, BMI and liver fibrosis were associated with steatosis > 30% in CHC, whereas only age and BMI were related to steatosis in CHB. Conclusion: These data may indicate that hepatitis C virus infection is a risk factor for insulin resistance.

Original languageEnglish
Pages (from-to)462-466
Number of pages5
JournalWorld Journal of Gastroenterology
Volume15
Issue number4
DOIs
Publication statusPublished - Jan 28 2009

Keywords

  • Diabetes
  • Hepatitis B virus
  • Hepatitis C virus
  • Insulin resistance
  • Metabolic syndrome

ASJC Scopus subject areas

  • Gastroenterology

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