Clinical features and lifestyle of patients with amyotrophic lateral sclerosis in Campania: Brief overview of an Italian database

Francesca Trojsi, Anna Sagnelli, Nicola Vanacore, Giovanni Piccirillo, Luca Daniele, Francesco Izzo, Anna Laiola, Alfonso Di Costanzo, Giovanni Savettieri, Maria Rosaria Monsurrò, Gioacchino Tedeschi

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Physical activity and occupational exposures appeared to play a relevant role in pathogenesis of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease of unknown origin. Materials and methods: We aimed to make an overview of the clinical characteristics and lifestyle (occupation and sport) of a population of 395 patients with ALS from Campania, in southern Italy. Results: ALS onset resulted anticipated of about 11 years in industry workers, whilst the more frequent site of onset among farmers was upper limbs. Compared to non-athletes, athletes, particularly soccer players, showed a 7 years anticipation of ALS onset, with higher mortality after 5 years. Discussion and conclusions: We suggest that subjects genetically prone to abnormal response to hypoxia during strenuous physical activity or exposed to neurotoxic agents, such as athletes, farmers or industry workers, might present increased risk to develop ALS. Future case-control and follow-up studies on our population should be implemented to deepen the present results.

Original languageEnglish
Pages (from-to)287-291
Number of pages5
JournalAnnali dell'Istituto Superiore di Sanita
Volume48
Issue number3
DOIs
Publication statusPublished - 2012

Keywords

  • Amyotrophic lateral sclerosis
  • Clinical database
  • Motor neuron diseases
  • Occupational exposure

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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