Clinical features and risk factors of autoimmune liver involvement in pediatric inflammatory bowel disease

Matteo Bramuzzo, Stefano Martelossi, Giuliano Torre, Sabrina Cardile, Serena Arrigo, Silvia Vignola, Federica Ferrari, Giovanna Zuin, Maria Teresa Illiceto, Marco Gasparetto, Salvatore Pellegrino, Claudio Romano, Giuseppe Maggiore, Marcella Montico, Marina Aloi

Research output: Contribution to journalArticlepeer-review


Objectives: Autoimmune liver disease is reported in up to 7.8% of children with inflammatory bowel disease. A distinct inflammatory bowel disease phenotype has been suggested in adults and in small pediatric cohorts. The aim of the study was to evaluate the features of inflammatory bowel disease associated with autoimmune liver diseases and to analyze the characteristics of the liver disease. Methods: Information on patients was obtained from the Italian Pediatric Inflammatory Bowel Disease Registry. Data of patients with and without autoimmune liver disease were compared. Results: Autoimmune liver disease was detected in 6.8% of the 677 patients enrolled and was significantly associated with the diagnosis of ulcerative colitis (83%), with pancolonic involvement (84%), and with perinuclear antineutrophil cytoplasmic antibody positivity (41%) (all Ps

Original languageEnglish
Pages (from-to)259-264
Number of pages6
JournalJournal of Pediatric Gastroenterology and Nutrition
Issue number2
Publication statusPublished - Jul 26 2016


  • Autoimmune hepatitis
  • Children
  • Inflammatory bowel disease
  • Overlap syndrome
  • Sclerosing cholangitis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Medicine(all)
  • Gastroenterology


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