Clinical features and risk factors of autoimmune liver involvement in pediatric inflammatory bowel disease

Matteo Bramuzzo; Stefano Martelossi; Giuliano Torre; Sabrina Cardile; Serena Arrigo; Silvia Vignola; Federica Ferrari; Giovanna Zuin; Maria Teresa Illiceto; Marco Gasparetto; Salvatore Pellegrino; Claudio Romano; Giuseppe Maggiore; Marcella Montico; Marina Aloi

doi:10.1097/MPG.0000000000001078

Clinical features and risk factors of autoimmune liver involvement in pediatric inflammatory bowel disease

Matteo Bramuzzo, Stefano Martelossi, Giuliano Torre, Sabrina Cardile, Serena Arrigo, Silvia Vignola, Federica Ferrari, Giovanna Zuin, Maria Teresa Illiceto, Marco Gasparetto, Salvatore Pellegrino, Claudio Romano, Giuseppe Maggiore, Marcella Montico, Marina Aloi

Research output: Contribution to journal › Article › peer-review

Abstract

Objectives: Autoimmune liver disease is reported in up to 7.8% of children with inflammatory bowel disease. A distinct inflammatory bowel disease phenotype has been suggested in adults and in small pediatric cohorts. The aim of the study was to evaluate the features of inflammatory bowel disease associated with autoimmune liver diseases and to analyze the characteristics of the liver disease. Methods: Information on patients was obtained from the Italian Pediatric Inflammatory Bowel Disease Registry. Data of patients with and without autoimmune liver disease were compared. Results: Autoimmune liver disease was detected in 6.8% of the 677 patients enrolled and was significantly associated with the diagnosis of ulcerative colitis (83%), with pancolonic involvement (84%), and with perinuclear antineutrophil cytoplasmic antibody positivity (41%) (all P_s

Original language	English
Pages (from-to)	259-264
Number of pages	6
Journal	Journal of Pediatric Gastroenterology and Nutrition
Volume	63
Issue number	2
DOIs	https://doi.org/10.1097/MPG.0000000000001078
Publication status	Published - Jul 26 2016

Keywords

Autoimmune hepatitis
Children
Inflammatory bowel disease
Overlap syndrome
Sclerosing cholangitis

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Medicine(all)
Gastroenterology

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10.1097/MPG.0000000000001078

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Bramuzzo, M., Martelossi, S., Torre, G., Cardile, S., Arrigo, S., Vignola, S., Ferrari, F., Zuin, G., Illiceto, M. T., Gasparetto, M., Pellegrino, S., Romano, C., Maggiore, G., Montico, M., & Aloi, M. (2016). Clinical features and risk factors of autoimmune liver involvement in pediatric inflammatory bowel disease. Journal of Pediatric Gastroenterology and Nutrition, 63(2), 259-264. https://doi.org/10.1097/MPG.0000000000001078

Clinical features and risk factors of autoimmune liver involvement in pediatric inflammatory bowel disease. / Bramuzzo, Matteo; Martelossi, Stefano; Torre, Giuliano; Cardile, Sabrina; Arrigo, Serena; Vignola, Silvia; Ferrari, Federica; Zuin, Giovanna; Illiceto, Maria Teresa; Gasparetto, Marco; Pellegrino, Salvatore; Romano, Claudio; Maggiore, Giuseppe; Montico, Marcella; Aloi, Marina.

In: Journal of Pediatric Gastroenterology and Nutrition, Vol. 63, No. 2, 26.07.2016, p. 259-264.

Research output: Contribution to journal › Article › peer-review

Bramuzzo, M, Martelossi, S, Torre, G, Cardile, S, Arrigo, S, Vignola, S, Ferrari, F, Zuin, G, Illiceto, MT, Gasparetto, M, Pellegrino, S, Romano, C, Maggiore, G, Montico, M & Aloi, M 2016, 'Clinical features and risk factors of autoimmune liver involvement in pediatric inflammatory bowel disease', Journal of Pediatric Gastroenterology and Nutrition, vol. 63, no. 2, pp. 259-264. https://doi.org/10.1097/MPG.0000000000001078

Bramuzzo, Matteo ; Martelossi, Stefano ; Torre, Giuliano ; Cardile, Sabrina ; Arrigo, Serena ; Vignola, Silvia ; Ferrari, Federica ; Zuin, Giovanna ; Illiceto, Maria Teresa ; Gasparetto, Marco ; Pellegrino, Salvatore ; Romano, Claudio ; Maggiore, Giuseppe ; Montico, Marcella ; Aloi, Marina. / Clinical features and risk factors of autoimmune liver involvement in pediatric inflammatory bowel disease. In: Journal of Pediatric Gastroenterology and Nutrition. 2016 ; Vol. 63, No. 2. pp. 259-264.

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AU - Vignola, Silvia

AU - Ferrari, Federica

AU - Zuin, Giovanna

AU - Illiceto, Maria Teresa

AU - Gasparetto, Marco

AU - Pellegrino, Salvatore

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AU - Maggiore, Giuseppe

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