Clinical frailty scale and outcome after coronary artery bypass grafting

Daniel Reichart, Stefano Rosato, Wail Nammas, Francesco Onorati, Magnus Dalén, Liesa Castro, Riccardo Gherli, Giuseppe Gatti, Ilaria Franzese, Giuseppe Faggian, Marisa De Feo, Sorosh Khodabandeh, Giuseppe Santarpino, Antonino S. Rubino, Daniele Maselli, Saverio Nardella, Antonio Salsano, Francesco Nicolini, Marco Zanobini, Matteo SaccocciKarl Bounader, Eeva Maija Kinnunen, Tuomas Tauriainen, Juhani Airaksinen, Fulvia Seccareccia, Giovanni Mariscalco, Vito G. Ruggieri, Andrea Perrotti, Fausto Biancari

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: The aim of this study was to assess the impact of frailty on the outcome after coronary artery bypass grafting (CABG) and whether it may improve the predictive ability of European System for Cardiac Operative Risk Evaluation (EuroSCORE II). METHODS: The Clinical Frailty Scale (CFS) was assessed preoperatively in patients undergoing isolated CABG from the multicentre E-CABG registry, and patients were stratified into 3 classes: scores 1-2, scores 3-4 and scores 5-7. RESULTS: Of the 6156 patients enrolled, 39.2% had CFS scores 1-2, 57.6% scores 3-4, and 3.2% scores 5-7. Logistic regression adjusted for multiple covariates showed that the CFS was an independent predictor of hospital/30-day mortality [CFS scores 3-4, odds ratio (OR) 3.95, 95% confidence interval (CI) 2.19-7.14; CFS scores 5-7, OR 5.90, 95% CI 2.67-13.05] and resulted in an Integrated Improvement Index of 1.3 (P 
Original languageEnglish
Pages (from-to)1102-1109
Number of pages8
JournalEuropean Journal of Cardio-thoracic Surgery
Volume54
Issue number6
DOIs
Publication statusPublished - Dec 1 2018

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Coronary Artery Bypass
Odds Ratio
Confidence Intervals
Registries
Logistic Models
Mortality

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Reichart, D., Rosato, S., Nammas, W., Onorati, F., Dalén, M., Castro, L., ... Biancari, F. (2018). Clinical frailty scale and outcome after coronary artery bypass grafting. European Journal of Cardio-thoracic Surgery, 54(6), 1102-1109. https://doi.org/10.1093/ejcts/ezy222

Clinical frailty scale and outcome after coronary artery bypass grafting. / Reichart, Daniel; Rosato, Stefano; Nammas, Wail; Onorati, Francesco; Dalén, Magnus; Castro, Liesa; Gherli, Riccardo; Gatti, Giuseppe; Franzese, Ilaria; Faggian, Giuseppe; De Feo, Marisa; Khodabandeh, Sorosh; Santarpino, Giuseppe; Rubino, Antonino S.; Maselli, Daniele; Nardella, Saverio; Salsano, Antonio; Nicolini, Francesco; Zanobini, Marco; Saccocci, Matteo; Bounader, Karl; Kinnunen, Eeva Maija; Tauriainen, Tuomas; Airaksinen, Juhani; Seccareccia, Fulvia; Mariscalco, Giovanni; Ruggieri, Vito G.; Perrotti, Andrea; Biancari, Fausto.

In: European Journal of Cardio-thoracic Surgery, Vol. 54, No. 6, 01.12.2018, p. 1102-1109.

Research output: Contribution to journalArticle

Reichart, D, Rosato, S, Nammas, W, Onorati, F, Dalén, M, Castro, L, Gherli, R, Gatti, G, Franzese, I, Faggian, G, De Feo, M, Khodabandeh, S, Santarpino, G, Rubino, AS, Maselli, D, Nardella, S, Salsano, A, Nicolini, F, Zanobini, M, Saccocci, M, Bounader, K, Kinnunen, EM, Tauriainen, T, Airaksinen, J, Seccareccia, F, Mariscalco, G, Ruggieri, VG, Perrotti, A & Biancari, F 2018, 'Clinical frailty scale and outcome after coronary artery bypass grafting', European Journal of Cardio-thoracic Surgery, vol. 54, no. 6, pp. 1102-1109. https://doi.org/10.1093/ejcts/ezy222
Reichart, Daniel ; Rosato, Stefano ; Nammas, Wail ; Onorati, Francesco ; Dalén, Magnus ; Castro, Liesa ; Gherli, Riccardo ; Gatti, Giuseppe ; Franzese, Ilaria ; Faggian, Giuseppe ; De Feo, Marisa ; Khodabandeh, Sorosh ; Santarpino, Giuseppe ; Rubino, Antonino S. ; Maselli, Daniele ; Nardella, Saverio ; Salsano, Antonio ; Nicolini, Francesco ; Zanobini, Marco ; Saccocci, Matteo ; Bounader, Karl ; Kinnunen, Eeva Maija ; Tauriainen, Tuomas ; Airaksinen, Juhani ; Seccareccia, Fulvia ; Mariscalco, Giovanni ; Ruggieri, Vito G. ; Perrotti, Andrea ; Biancari, Fausto. / Clinical frailty scale and outcome after coronary artery bypass grafting. In: European Journal of Cardio-thoracic Surgery. 2018 ; Vol. 54, No. 6. pp. 1102-1109.
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AU - Reichart, Daniel

AU - Rosato, Stefano

AU - Nammas, Wail

AU - Onorati, Francesco

AU - Dalén, Magnus

AU - Castro, Liesa

AU - Gherli, Riccardo

AU - Gatti, Giuseppe

AU - Franzese, Ilaria

AU - Faggian, Giuseppe

AU - De Feo, Marisa

AU - Khodabandeh, Sorosh

AU - Santarpino, Giuseppe

AU - Rubino, Antonino S.

AU - Maselli, Daniele

AU - Nardella, Saverio

AU - Salsano, Antonio

AU - Nicolini, Francesco

AU - Zanobini, Marco

AU - Saccocci, Matteo

AU - Bounader, Karl

AU - Kinnunen, Eeva Maija

AU - Tauriainen, Tuomas

AU - Airaksinen, Juhani

AU - Seccareccia, Fulvia

AU - Mariscalco, Giovanni

AU - Ruggieri, Vito G.

AU - Perrotti, Andrea

AU - Biancari, Fausto

PY - 2018/12/1

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N2 - OBJECTIVES: The aim of this study was to assess the impact of frailty on the outcome after coronary artery bypass grafting (CABG) and whether it may improve the predictive ability of European System for Cardiac Operative Risk Evaluation (EuroSCORE II). METHODS: The Clinical Frailty Scale (CFS) was assessed preoperatively in patients undergoing isolated CABG from the multicentre E-CABG registry, and patients were stratified into 3 classes: scores 1-2, scores 3-4 and scores 5-7. RESULTS: Of the 6156 patients enrolled, 39.2% had CFS scores 1-2, 57.6% scores 3-4, and 3.2% scores 5-7. Logistic regression adjusted for multiple covariates showed that the CFS was an independent predictor of hospital/30-day mortality [CFS scores 3-4, odds ratio (OR) 3.95, 95% confidence interval (CI) 2.19-7.14; CFS scores 5-7, OR 5.90, 95% CI 2.67-13.05] and resulted in an Integrated Improvement Index of 1.3 (P 

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