Clinical-grade human neural stem cells promote reparative neovascularization in mouse models of hindlimb ischemia

Rajesh Katare; Paul Stroemer; Caroline Hicks; Lara Stevanato; Sara Patel; Randolph Corteling; Erik Miljan; Indira Vishnubhatla; John Sinden; Paolo Madeddu

doi:10.1161/ATVBAHA.113.302592

Clinical-grade human neural stem cells promote reparative neovascularization in mouse models of hindlimb ischemia

Rajesh Katare, Paul Stroemer, Caroline Hicks, Lara Stevanato, Sara Patel, Randolph Corteling, Erik Miljan, Indira Vishnubhatla, John Sinden, Paolo Madeddu

IRCCS Multimedica

Research output: Contribution to journal › Article

Abstract

OBJECTIVE - : CTX0E03 (CTX) is a clinical-grade human neural stem cell (hNSC) line that promotes angiogenesis and neurogenesis in a preclinical model of stroke and is now under clinical development for stroke disability. We evaluated the therapeutic activity of intramuscular CTX hNSC implantation in murine models of hindlimb ischemia for potential translation to clinical studies in critical limb ischemia. APPROACH AND RESULTS - : Immunodeficient (CD-1 Fox) mice acutely treated with hNSCs had overall significantly increased rates and magnitude of recovery of surface blood flow (laser Doppler), limb muscle perfusion (fluorescent microspheres, P

Original language	English
Pages (from-to)	408-418
Number of pages	11
Journal	Arteriosclerosis, Thrombosis, and Vascular Biology
Volume	34
Issue number	2
DOIs	https://doi.org/10.1161/ATVBAHA.113.302592
Publication status	Published - Feb 2014

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Keywords

angiogenesis inducing agents
neural stem cells
peripheral arterial disease
renal circulation

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

Cite this

Katare, R., Stroemer, P., Hicks, C., Stevanato, L., Patel, S., Corteling, R., Miljan, E., Vishnubhatla, I., Sinden, J., & Madeddu, P. (2014). Clinical-grade human neural stem cells promote reparative neovascularization in mouse models of hindlimb ischemia. Arteriosclerosis, Thrombosis, and Vascular Biology, 34(2), 408-418. https://doi.org/10.1161/ATVBAHA.113.302592

Clinical-grade human neural stem cells promote reparative neovascularization in mouse models of hindlimb ischemia. / Katare, Rajesh; Stroemer, Paul; Hicks, Caroline; Stevanato, Lara; Patel, Sara; Corteling, Randolph; Miljan, Erik; Vishnubhatla, Indira; Sinden, John; Madeddu, Paolo.

In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 34, No. 2, 02.2014, p. 408-418.

Research output: Contribution to journal › Article

Katare, Rajesh ; Stroemer, Paul ; Hicks, Caroline ; Stevanato, Lara ; Patel, Sara ; Corteling, Randolph ; Miljan, Erik ; Vishnubhatla, Indira ; Sinden, John ; Madeddu, Paolo. / Clinical-grade human neural stem cells promote reparative neovascularization in mouse models of hindlimb ischemia. In: Arteriosclerosis, Thrombosis, and Vascular Biology. 2014 ; Vol. 34, No. 2. pp. 408-418.

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Access to Document

10.1161/ATVBAHA.113.302592