Clinical-grade human neural stem cells promote reparative neovascularization in mouse models of hindlimb ischemia

Rajesh Katare, Paul Stroemer, Caroline Hicks, Lara Stevanato, Sara Patel, Randolph Corteling, Erik Miljan, Indira Vishnubhatla, John Sinden, Paolo Madeddu

Research output: Contribution to journalArticle

Abstract

OBJECTIVE - : CTX0E03 (CTX) is a clinical-grade human neural stem cell (hNSC) line that promotes angiogenesis and neurogenesis in a preclinical model of stroke and is now under clinical development for stroke disability. We evaluated the therapeutic activity of intramuscular CTX hNSC implantation in murine models of hindlimb ischemia for potential translation to clinical studies in critical limb ischemia. APPROACH AND RESULTS - : Immunodeficient (CD-1 Fox) mice acutely treated with hNSCs had overall significantly increased rates and magnitude of recovery of surface blood flow (laser Doppler), limb muscle perfusion (fluorescent microspheres, P

Original languageEnglish
Pages (from-to)408-418
Number of pages11
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume34
Issue number2
DOIs
Publication statusPublished - Feb 2014

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Keywords

  • angiogenesis inducing agents
  • neural stem cells
  • peripheral arterial disease
  • renal circulation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Katare, R., Stroemer, P., Hicks, C., Stevanato, L., Patel, S., Corteling, R., Miljan, E., Vishnubhatla, I., Sinden, J., & Madeddu, P. (2014). Clinical-grade human neural stem cells promote reparative neovascularization in mouse models of hindlimb ischemia. Arteriosclerosis, Thrombosis, and Vascular Biology, 34(2), 408-418. https://doi.org/10.1161/ATVBAHA.113.302592