Abstract
OBJECTIVE - : CTX0E03 (CTX) is a clinical-grade human neural stem cell (hNSC) line that promotes angiogenesis and neurogenesis in a preclinical model of stroke and is now under clinical development for stroke disability. We evaluated the therapeutic activity of intramuscular CTX hNSC implantation in murine models of hindlimb ischemia for potential translation to clinical studies in critical limb ischemia. APPROACH AND RESULTS - : Immunodeficient (CD-1 Fox) mice acutely treated with hNSCs had overall significantly increased rates and magnitude of recovery of surface blood flow (laser Doppler), limb muscle perfusion (fluorescent microspheres, P
| Original language | English |
|---|---|
| Pages (from-to) | 408-418 |
| Number of pages | 11 |
| Journal | Arteriosclerosis, Thrombosis, and Vascular Biology |
| Volume | 34 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2014 |
Fingerprint
Keywords
- angiogenesis inducing agents
- neural stem cells
- peripheral arterial disease
- renal circulation
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Clinical-grade human neural stem cells promote reparative neovascularization in mouse models of hindlimb ischemia. / Katare, Rajesh; Stroemer, Paul; Hicks, Caroline; Stevanato, Lara; Patel, Sara; Corteling, Randolph; Miljan, Erik; Vishnubhatla, Indira; Sinden, John; Madeddu, Paolo.
In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 34, No. 2, 02.2014, p. 408-418.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clinical-grade human neural stem cells promote reparative neovascularization in mouse models of hindlimb ischemia
AU - Katare, Rajesh
AU - Stroemer, Paul
AU - Hicks, Caroline
AU - Stevanato, Lara
AU - Patel, Sara
AU - Corteling, Randolph
AU - Miljan, Erik
AU - Vishnubhatla, Indira
AU - Sinden, John
AU - Madeddu, Paolo
PY - 2014/2
Y1 - 2014/2
N2 - OBJECTIVE - : CTX0E03 (CTX) is a clinical-grade human neural stem cell (hNSC) line that promotes angiogenesis and neurogenesis in a preclinical model of stroke and is now under clinical development for stroke disability. We evaluated the therapeutic activity of intramuscular CTX hNSC implantation in murine models of hindlimb ischemia for potential translation to clinical studies in critical limb ischemia. APPROACH AND RESULTS - : Immunodeficient (CD-1 Fox) mice acutely treated with hNSCs had overall significantly increased rates and magnitude of recovery of surface blood flow (laser Doppler), limb muscle perfusion (fluorescent microspheres, P
AB - OBJECTIVE - : CTX0E03 (CTX) is a clinical-grade human neural stem cell (hNSC) line that promotes angiogenesis and neurogenesis in a preclinical model of stroke and is now under clinical development for stroke disability. We evaluated the therapeutic activity of intramuscular CTX hNSC implantation in murine models of hindlimb ischemia for potential translation to clinical studies in critical limb ischemia. APPROACH AND RESULTS - : Immunodeficient (CD-1 Fox) mice acutely treated with hNSCs had overall significantly increased rates and magnitude of recovery of surface blood flow (laser Doppler), limb muscle perfusion (fluorescent microspheres, P
KW - angiogenesis inducing agents
KW - neural stem cells
KW - peripheral arterial disease
KW - renal circulation
UR - http://www.scopus.com/inward/record.url?scp=84893391374&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84893391374&partnerID=8YFLogxK
U2 - 10.1161/ATVBAHA.113.302592
DO - 10.1161/ATVBAHA.113.302592
M3 - Article
C2 - 24202301
AN - SCOPUS:84893391374
VL - 34
SP - 408
EP - 418
JO - Arteriosclerosis, Thrombosis, and Vascular Biology
JF - Arteriosclerosis, Thrombosis, and Vascular Biology
SN - 1079-5642
IS - 2
ER -