Abstract
80 children with selective immunoglobulin A (IgA) deficiency-40 with severe deficiency (serum IgA 5 mg/dl but less than minus 2 SD of the age-normal mean)-were followed up for 1·5 to 9 years; during which their serum and salivary IgA levels were measured periodically and the number and type of infections they had were recorded. In the partial deficiency group serum IgA rose to normal levels in half the group at a median age of 14 years and at a median time of 4 years after diagnosis, but they did not reach the normal range in the severe deficiency group. Pneumonia occurred more frequently in the severe than in the partial deficiency group. In addition, 11 of the 12 severely IgA deficient patients who had pneumonia had levels of both serum and salivary IgA of less than 0·5 mg/dl, and only 1 had detectable serum IgA levels. These data indicate that in childhood severe IgA deficiency is persistent and predisposes to pneumonia, whereas partial IgA deficiency is often transient and only occasionally associated with pneumonia.
| Original language | English |
|---|---|
| Pages (from-to) | 829-831 |
| Number of pages | 3 |
| Journal | Lancet |
| Volume | 327 |
| Issue number | 8485 |
| DOIs | |
| Publication status | Published - Apr 12 1986 |
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ASJC Scopus subject areas
- Medicine(all)
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CLINICAL HETEROGENEITY AND REVERSIBILITY OF SELECTIVE IMMUNOGLOBULIN A DEFICIENCY IN 80 CHILDREN. / Plebani, Alessandro; Monafo, Virginia; Ugazio, AlbertoG; Roberto Burgio, G.
In: Lancet, Vol. 327, No. 8485, 12.04.1986, p. 829-831.Research output: Contribution to journal › Article
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TY - JOUR
T1 - CLINICAL HETEROGENEITY AND REVERSIBILITY OF SELECTIVE IMMUNOGLOBULIN A DEFICIENCY IN 80 CHILDREN
AU - Plebani, Alessandro
AU - Monafo, Virginia
AU - Ugazio, AlbertoG
AU - Roberto Burgio, G.
PY - 1986/4/12
Y1 - 1986/4/12
N2 - 80 children with selective immunoglobulin A (IgA) deficiency-40 with severe deficiency (serum IgA 5 mg/dl but less than minus 2 SD of the age-normal mean)-were followed up for 1·5 to 9 years; during which their serum and salivary IgA levels were measured periodically and the number and type of infections they had were recorded. In the partial deficiency group serum IgA rose to normal levels in half the group at a median age of 14 years and at a median time of 4 years after diagnosis, but they did not reach the normal range in the severe deficiency group. Pneumonia occurred more frequently in the severe than in the partial deficiency group. In addition, 11 of the 12 severely IgA deficient patients who had pneumonia had levels of both serum and salivary IgA of less than 0·5 mg/dl, and only 1 had detectable serum IgA levels. These data indicate that in childhood severe IgA deficiency is persistent and predisposes to pneumonia, whereas partial IgA deficiency is often transient and only occasionally associated with pneumonia.
AB - 80 children with selective immunoglobulin A (IgA) deficiency-40 with severe deficiency (serum IgA 5 mg/dl but less than minus 2 SD of the age-normal mean)-were followed up for 1·5 to 9 years; during which their serum and salivary IgA levels were measured periodically and the number and type of infections they had were recorded. In the partial deficiency group serum IgA rose to normal levels in half the group at a median age of 14 years and at a median time of 4 years after diagnosis, but they did not reach the normal range in the severe deficiency group. Pneumonia occurred more frequently in the severe than in the partial deficiency group. In addition, 11 of the 12 severely IgA deficient patients who had pneumonia had levels of both serum and salivary IgA of less than 0·5 mg/dl, and only 1 had detectable serum IgA levels. These data indicate that in childhood severe IgA deficiency is persistent and predisposes to pneumonia, whereas partial IgA deficiency is often transient and only occasionally associated with pneumonia.
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UR - http://www.scopus.com/inward/citedby.url?scp=0022573874&partnerID=8YFLogxK
U2 - 10.1016/S0140-6736(86)90940-2
DO - 10.1016/S0140-6736(86)90940-2
M3 - Article
C2 - 2870316
AN - SCOPUS:0022573874
VL - 327
SP - 829
EP - 831
JO - The Lancet
JF - The Lancet
SN - 0140-6736
IS - 8485
ER -