Clinical heterogeneity of de novo 11q deletion chronic lymphocytic leukaemia: Prognostic relevance of extent of 11q deleted nuclei inside leukemic clone

Roberto Marasca, Rossana Maffei, Silvia Martinelli, Stefania Fiorcari, Jenny Bulgarelli, Giulia Debbia, Davide Rossi, Francesca Maria Rossi, Gian Matteo Rigolin, Sara Martinelli, Valter Gattei, Giovanni Del Poeta, Luca Laurenti, Francesco Forconi, Marco Montillo, Gianluca Gaidano, Mario Luppi

Research output: Contribution to journalArticle

Abstract

Deletion on the long arm of chromosome 11 occurs in 5-20% of chronic lymphocytic leukaemia (CLL) patients. We analysed clinical-biological characteristics of 131 CLL patients carrying 11q deletion documented before therapy (de novo 11q deleted CLL). De novo 11q deleted CLL were characterized by high frequencies of unmutated immunoglobulin variable heavy genes, multiple fluorescence in situ hybridization aberrations and lymph node involvement. Factors significantly associated with shorter time to first treatment (TTFT) were advanced Binet stages, high white blood cell count, increased β2-microglobulin levels, 17p in addition, splenomegaly and more extensive lymphadenopathy. We found that patients with

Original languageEnglish
Pages (from-to)348-355
Number of pages8
JournalHematological Oncology
Volume31
Issue number2
DOIs
Publication statusPublished - Jun 2013

Keywords

  • 11q deleted nuclei
  • Chronic lymphocytic leukaemia
  • Clinical outcome

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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    Marasca, R., Maffei, R., Martinelli, S., Fiorcari, S., Bulgarelli, J., Debbia, G., Rossi, D., Rossi, F. M., Rigolin, G. M., Martinelli, S., Gattei, V., Del Poeta, G., Laurenti, L., Forconi, F., Montillo, M., Gaidano, G., & Luppi, M. (2013). Clinical heterogeneity of de novo 11q deletion chronic lymphocytic leukaemia: Prognostic relevance of extent of 11q deleted nuclei inside leukemic clone. Hematological Oncology, 31(2), 348-355. https://doi.org/10.1002/hon.2028