Clinical, histological and immunopathological features of 58 patients with subacute cutaneous lupus erythematosus. A review by the Italian Group of Immunodermatology

Aurora Parodi, Marzia Caproni, Carla Cardinali, Elisabetta Bernacchi, Alessandra Fuligni, Giuseppe De Panfilis, Cristina Zane, Manuela Papini, Farnase Cleto Veller, Mario Vaccaro, Paolo Fabbri

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Subacute cutaneous lupus erythematosus (SCLE) is a distinct subset of cutaneous lupus erythematosus clinically characterized by psoriasiform and/or annular lesions and by a mild or absent systemic involvement. Objective: The Italian Group of Immunodermatology of the Italian Society of Dermatology and Venereology reviewed the cases of SCLE seen in 10 years (1987-1996). Patients: Forty-six women and 12 men have been retrospectively studied, 42% had annular lesions, 39% psoriasiform ones and 16% both. Results: Lesions were mainly localized on the neck and face and relapsed in spring and autumn. Seventeen patients had 4 or more American College of Rheumatology criteria and could be classified as having systemic lupus erythematosus. The most frequent histopathological alterations were epidermal atrophy, hydropic degeneration of the basal layer and perivascular lymphocytic infiltrate. Deposits of immunoglobulins and C3 at the dermoepidermal junction on the clinically involved skin were present in 86% of the patients. Dust-like particles in the epidermis were only found in 3% of cases. Anti-Ro/SSA antibodies were found in 71% of the cases and anti-dsDNA only in 5% of cases. Conclusions: SCLE is a particular subset of cutaneous lupus erythematosus with peculiar clinical and immunopathological features. Copyright ® 2000 S. Karger AG, Basel.

Original languageEnglish
Pages (from-to)6-10
Number of pages5
JournalDermatology
Volume200
Issue number1
Publication statusPublished - 2000

ASJC Scopus subject areas

  • Dermatology

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