Clinical impact of COVID-19 in a single-center cohort of a prospective study in cancer patients receiving immunotherapy

Melissa Bersanelli, Teresa Zielli, Fabiana Perrone, Chiara Casartelli, Fabiana Prattico, Elena Rapacchi, Roberta Camisa, Michele Tognetto, Alberto Clemente, Diana Giannarelli, Sara Elena Rebuzzi, Alessandro Leonetti, Paola Bordi, Marcello Tiseo, Sebastiano Buti

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: Evaluating the incidence and course of COVID-19 in cancer patients treated with immunotherapy. Patients & methods: We reported the influenza-like illness events with diagnosis of COVID-19 within the patient cohort enrolled in the prospective observational multicenter INVIDIa-2 study in the single center of Parma. Results: Among 53 patients, eight experienced influenza-like illness during the influenza season 2019/2020, and three of them had diagnosis of COVID-19. They were males, elderly, with cardiovascular disease. Radiological features of COVID-19 pneumonitis were found in all of three cases, although the pharyngeal swab resulted positive in only two. Two of these three patients died due to respiratory failure. Conclusion: Cancer patients are at high risk of severe events from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

Original languageEnglish
Pages (from-to)1139-1148
Number of pages10
JournalImmunotherapy
Volume12
Issue number15
DOIs
Publication statusPublished - Oct 2020

Keywords

  • anti-PD-1
  • cancer patients
  • COVID-19
  • immune checkpoint inhibitors
  • immunotherapy
  • influenza vaccine
  • interstitial pneumonia
  • SARS-CoV2

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology

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