Clinical impact of Pancreatic metastases from renal cell carcinoma: A multicenter retrospective analysis

Paolo Grassi, Ludovic Doucet, Palma Giglione, Viktor Grünwald, Bohuslav Melichar, Luca Galli, Ugo De Giorgi, Roberto Sabbatini, Cinzia Ortega, Matteo Santoni, Aristotelis Bamias, Elena Verzoni, Lisa Derosa, Hana Studentova, Monica Pacifici, Jorgelina Coppa, Vincenzo Mazzaferro, Filippode Braud, Camillo Porta, Bernard EscudierGiuseppe Procopio

Research output: Contribution to journalArticlepeer-review

Abstract

Pancreatic metastases from renal cell carcinoma are uncommon and their prognostic significance is not well defined. In this analysis we evaluated the outcome of patients with pancreatic metastases treated with either targeted therapies or local treatment to the pancreas. Patients with pancreatic metastases from renal cell carcinoma treated between 1993 and 2014 were identified from 11 European centers. Clinical records were retrospectively reviewed. Kaplan-Meier method and log-rank test were used to evaluate progression-free survival and overall survival. Cox's proportional hazard models were used for survival analysis. In total, 276 PM patients were evaluated, including 77 (28%) patients treated by either surgery or radiotherapy to the pancreas, and 256 (93%) who received systemic therapy. Median time from nephrectomy to diagnosis of pancreatic metastases was 91 months (IQR 54-142). Disease control rate after first-line TTs was 84%, with a median progression-free survival of 12 months (95% CI 10-14). Median overall survival was 73 months (95% CI 61-86) with a 5-year OS of 58%. Median OS of patients treated with local treatment was 106 months (95% CI 78-204) with a 5-year overall survival of 75%. On multivariable analysis, nephrectomy (HR 5.31; 95%CI 2.36-11.92; p

Original languageEnglish
Article numbere0151662
JournalPLoS One
Volume11
Issue number4
DOIs
Publication statusPublished - Apr 1 2016

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Fingerprint

Dive into the research topics of 'Clinical impact of Pancreatic metastases from renal cell carcinoma: A multicenter retrospective analysis'. Together they form a unique fingerprint.

Cite this