Clinical impact of recurrently mutated genes on lymphoma diagnostics: State-of-the-art and beyond

Richard Rosenquist, Andreas Rosenwald, Ming Qing Du, Gianluca Gaidano, Patricia Groenen, Andrew Wotherspoon, Paolo Ghia, Philippe Gaulard, Elias Campo, Kostas Stamatopoulos

Research output: Contribution to journalReview article

Abstract

Similar to the inherent clinical heterogeneity of most, if not all, lymphoma entities, the genetic landscape of these tumors is markedly complex in the majority of cases, with a rapidly growing list of recurrently mutated genes discovered in recent years by next-generation sequencing technology. Whilst a few genes have been implied to have diagnostic, prognostic and even predictive impact, most gene mutations still require rigorous validation in larger, preferably prospective patient series, to scrutinize their potential role in lymphoma diagnostics and patient management. In selected entities, a predominantly mutated gene is identified in almost all cases (e.g. Waldenström’s macroglobulinemia/ lymphoplasmacytic lymphoma and hairy-cell leukemia), while for the vast majority of lymphomas a quite diverse mutation pattern is observed, with a limited number of frequently mutated genes followed by a seemingly endless tail of genes with mutations at a low frequency. Herein, the European Expert Group on NGS-based Diagnostics in Lymphomas (EGNL) summarizes the current status of this ever-evolving field, and, based on the present evidence level, segregates mutations into the following categories: i) immediate impact on treatment decisions, ii) diagnostic impact, iii) prognostic impact, iv) potential clinical impact in the near future, or v) should only be considered for research purposes. In the coming years, coordinated efforts aiming to apply targeted next-generation sequencing in large patient series will be needed in order to elucidate if a particular gene mutation will have an immediate impact on the lymphoma classification, and ultimately aid clinical decision making.

Original languageEnglish
Pages (from-to)1002-1009
Number of pages8
JournalHaematologica
Volume101
Issue number9
DOIs
Publication statusPublished - 2016

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'Clinical impact of recurrently mutated genes on lymphoma diagnostics: State-of-the-art and beyond'. Together they form a unique fingerprint.

  • Cite this

    Rosenquist, R., Rosenwald, A., Du, M. Q., Gaidano, G., Groenen, P., Wotherspoon, A., Ghia, P., Gaulard, P., Campo, E., & Stamatopoulos, K. (2016). Clinical impact of recurrently mutated genes on lymphoma diagnostics: State-of-the-art and beyond. Haematologica, 101(9), 1002-1009. https://doi.org/10.3324/haematol.2015.134510