Clinical implications of DSM-IV subtyping of bipolar disorders in referred children and adolescents

Gabriele Masi, Giulio Perugi, Stefania Millepiedi, Maria Mucci, Cinzia Pari, Chiara Pfanner, Stefano Berloffa, Cristina Toni

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

OBJECTIVE: According to DSM-IV, bipolar disorders (BDs) include four subtypes, BD I, BD II, cyclothymic disorder, and BD not otherwise specified (NOS). We explore the clinical implications of this subtyping in a naturalistic sample of referred youths with BD I, BD II, and BD-NOS. METHOD: The sample consisted of 217 patients, 135 males and 82 females, ages between 8 and 18 years (mean age, 13.6 ± 2.9 years), diagnosed according to historical information, prolonged observations, and a structured clinical interview (Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime version). The location of the study was the Stella Maris Scientific Institute of Child Neurology and Psychiatry of Pisa (Italy). RESULTS: Seventy-eight patients (35.9%) had BD I, 97 (44.7%) had BD II, and 42 (19.4%) had BD-NOS. Patients with BD I presented more frequently psychotic symptoms and elated rather than irritable mood. Patients with BD II were less severely impaired, presented more frequently depression as the intake affective episode, and had the highest comorbidity with anxiety disorders. Patients with BD-NOS presented an earlier onset of the disorder, a chronic rather than episodic course, an irritable rather than an elated mood, and a more frequent comorbidity with attention-deficit/hyperactivity disorder and oppositional defiant disorder. CONCLUSIONS: DSM-IV categorization of BD may have meaningful implications in youths, but needs to be detailed further. Copyright 2007

Original languageEnglish
Pages (from-to)1299-1306
Number of pages8
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Volume46
Issue number10
DOIs
Publication statusPublished - Oct 2007

Fingerprint

Bipolar Disorder
Diagnostic and Statistical Manual of Mental Disorders
Cyclothymic Disorder
Irritable Mood
Comorbidity
Attention Deficit and Disruptive Behavior Disorders
Child Psychiatry
Attention Deficit Disorder with Hyperactivity
Neurology
Anxiety Disorders
Mood Disorders
Italy
Schizophrenia
Appointments and Schedules
Interviews
Depression

Keywords

  • Bipolar disorder
  • Course
  • Mania
  • Phenotype

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Developmental and Educational Psychology

Cite this

Clinical implications of DSM-IV subtyping of bipolar disorders in referred children and adolescents. / Masi, Gabriele; Perugi, Giulio; Millepiedi, Stefania; Mucci, Maria; Pari, Cinzia; Pfanner, Chiara; Berloffa, Stefano; Toni, Cristina.

In: Journal of the American Academy of Child and Adolescent Psychiatry, Vol. 46, No. 10, 10.2007, p. 1299-1306.

Research output: Contribution to journalArticle

Masi, Gabriele ; Perugi, Giulio ; Millepiedi, Stefania ; Mucci, Maria ; Pari, Cinzia ; Pfanner, Chiara ; Berloffa, Stefano ; Toni, Cristina. / Clinical implications of DSM-IV subtyping of bipolar disorders in referred children and adolescents. In: Journal of the American Academy of Child and Adolescent Psychiatry. 2007 ; Vol. 46, No. 10. pp. 1299-1306.
@article{f5c7f44867634426a2b457e7b865009f,
title = "Clinical implications of DSM-IV subtyping of bipolar disorders in referred children and adolescents",
abstract = "OBJECTIVE: According to DSM-IV, bipolar disorders (BDs) include four subtypes, BD I, BD II, cyclothymic disorder, and BD not otherwise specified (NOS). We explore the clinical implications of this subtyping in a naturalistic sample of referred youths with BD I, BD II, and BD-NOS. METHOD: The sample consisted of 217 patients, 135 males and 82 females, ages between 8 and 18 years (mean age, 13.6 ± 2.9 years), diagnosed according to historical information, prolonged observations, and a structured clinical interview (Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime version). The location of the study was the Stella Maris Scientific Institute of Child Neurology and Psychiatry of Pisa (Italy). RESULTS: Seventy-eight patients (35.9{\%}) had BD I, 97 (44.7{\%}) had BD II, and 42 (19.4{\%}) had BD-NOS. Patients with BD I presented more frequently psychotic symptoms and elated rather than irritable mood. Patients with BD II were less severely impaired, presented more frequently depression as the intake affective episode, and had the highest comorbidity with anxiety disorders. Patients with BD-NOS presented an earlier onset of the disorder, a chronic rather than episodic course, an irritable rather than an elated mood, and a more frequent comorbidity with attention-deficit/hyperactivity disorder and oppositional defiant disorder. CONCLUSIONS: DSM-IV categorization of BD may have meaningful implications in youths, but needs to be detailed further. Copyright 2007",
keywords = "Bipolar disorder, Course, Mania, Phenotype",
author = "Gabriele Masi and Giulio Perugi and Stefania Millepiedi and Maria Mucci and Cinzia Pari and Chiara Pfanner and Stefano Berloffa and Cristina Toni",
year = "2007",
month = "10",
doi = "10.1097/chi.0b013e3180f62eba",
language = "English",
volume = "46",
pages = "1299--1306",
journal = "Journal of the American Academy of Child and Adolescent Psychiatry",
issn = "0890-8567",
publisher = "Elsevier Limited",
number = "10",

}

TY - JOUR

T1 - Clinical implications of DSM-IV subtyping of bipolar disorders in referred children and adolescents

AU - Masi, Gabriele

AU - Perugi, Giulio

AU - Millepiedi, Stefania

AU - Mucci, Maria

AU - Pari, Cinzia

AU - Pfanner, Chiara

AU - Berloffa, Stefano

AU - Toni, Cristina

PY - 2007/10

Y1 - 2007/10

N2 - OBJECTIVE: According to DSM-IV, bipolar disorders (BDs) include four subtypes, BD I, BD II, cyclothymic disorder, and BD not otherwise specified (NOS). We explore the clinical implications of this subtyping in a naturalistic sample of referred youths with BD I, BD II, and BD-NOS. METHOD: The sample consisted of 217 patients, 135 males and 82 females, ages between 8 and 18 years (mean age, 13.6 ± 2.9 years), diagnosed according to historical information, prolonged observations, and a structured clinical interview (Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime version). The location of the study was the Stella Maris Scientific Institute of Child Neurology and Psychiatry of Pisa (Italy). RESULTS: Seventy-eight patients (35.9%) had BD I, 97 (44.7%) had BD II, and 42 (19.4%) had BD-NOS. Patients with BD I presented more frequently psychotic symptoms and elated rather than irritable mood. Patients with BD II were less severely impaired, presented more frequently depression as the intake affective episode, and had the highest comorbidity with anxiety disorders. Patients with BD-NOS presented an earlier onset of the disorder, a chronic rather than episodic course, an irritable rather than an elated mood, and a more frequent comorbidity with attention-deficit/hyperactivity disorder and oppositional defiant disorder. CONCLUSIONS: DSM-IV categorization of BD may have meaningful implications in youths, but needs to be detailed further. Copyright 2007

AB - OBJECTIVE: According to DSM-IV, bipolar disorders (BDs) include four subtypes, BD I, BD II, cyclothymic disorder, and BD not otherwise specified (NOS). We explore the clinical implications of this subtyping in a naturalistic sample of referred youths with BD I, BD II, and BD-NOS. METHOD: The sample consisted of 217 patients, 135 males and 82 females, ages between 8 and 18 years (mean age, 13.6 ± 2.9 years), diagnosed according to historical information, prolonged observations, and a structured clinical interview (Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime version). The location of the study was the Stella Maris Scientific Institute of Child Neurology and Psychiatry of Pisa (Italy). RESULTS: Seventy-eight patients (35.9%) had BD I, 97 (44.7%) had BD II, and 42 (19.4%) had BD-NOS. Patients with BD I presented more frequently psychotic symptoms and elated rather than irritable mood. Patients with BD II were less severely impaired, presented more frequently depression as the intake affective episode, and had the highest comorbidity with anxiety disorders. Patients with BD-NOS presented an earlier onset of the disorder, a chronic rather than episodic course, an irritable rather than an elated mood, and a more frequent comorbidity with attention-deficit/hyperactivity disorder and oppositional defiant disorder. CONCLUSIONS: DSM-IV categorization of BD may have meaningful implications in youths, but needs to be detailed further. Copyright 2007

KW - Bipolar disorder

KW - Course

KW - Mania

KW - Phenotype

UR - http://www.scopus.com/inward/record.url?scp=34648825250&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34648825250&partnerID=8YFLogxK

U2 - 10.1097/chi.0b013e3180f62eba

DO - 10.1097/chi.0b013e3180f62eba

M3 - Article

C2 - 17885571

AN - SCOPUS:34648825250

VL - 46

SP - 1299

EP - 1306

JO - Journal of the American Academy of Child and Adolescent Psychiatry

JF - Journal of the American Academy of Child and Adolescent Psychiatry

SN - 0890-8567

IS - 10

ER -